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4D transcranial focused ultrasonic neuroimaging method based on acoustoelectric effect

A technology of focused ultrasound and acoustoelectric effect, which is applied in the field of neurological functional imaging, can solve the problems of limited resolution and positioning accuracy, monitoring deep brain function, and it is difficult to have both high time and high spatial resolution, so as to overcome spatial resolution. Low rate, improved time resolution and spatial resolution, considerable social and economic benefits

Active Publication Date: 2019-04-19
TIANJIN UNIV
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AI Technical Summary

Problems solved by technology

Taking scalp EEG as an example, it is difficult to have both high temporal and high spatial resolution
The current EEG technology based on scalp electrode collection can obtain electrophysiological data with a frequency up to 1kHz, but most of the EEG signals obtained by it are endogenously active below 100Hz
Moreover, the local EEG signals picked up by extracranial electrodes only come from superficial brain structures, and the resolution and positioning accuracy are also very limited.
This makes it nearly impossible to monitor deep brain function extracranially based on scalp EEG

Method used

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  • 4D transcranial focused ultrasonic neuroimaging method based on acoustoelectric effect
  • 4D transcranial focused ultrasonic neuroimaging method based on acoustoelectric effect
  • 4D transcranial focused ultrasonic neuroimaging method based on acoustoelectric effect

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Embodiment 1

[0037] A 4D transcranial focused ultrasound neuroimaging method based on acoustoelectric effects, see figure 1 , the method includes the following steps:

[0038] 101: Use a focused ultrasound signal generator and a transducer to realize the generation and emission of focused ultrasound signals, and determine the characteristics of focused ultrasound under different parameters;

[0039] 102: Install and connect neuroelectric signal acquisition equipment consisting of EEG electrodes, EEG amplifiers, EEG filter EEG acquisition systems, and neuroelectric signal measurement systems based on ultrasonic modulation;

[0040] 103: Ultrasound propagates through the cranium and focuses on a certain position. Based on the principle of acoustic-electric effect, the scalp EEG signal modulated by ultrasound is collected, that is, the acoustic-electric signal;

[0041] 104: Through the amplitude, frequency, and phase correlation of the acoustic-electric signal and the activation source sign...

Embodiment 2

[0044] The scheme in embodiment 1 is further introduced below in conjunction with calculation formula and examples, see the following description for details:

[0045] The acoustoelectric effect is a basic physical phenomenon of electrical modulation by ultrasound, and it is also the physical basis of acoustoelectric imaging. Specifically refers to: when focused ultrasonic waves pass through biological fluids or tissues, local (focused area) conductivity changes (determined by the frequency of ultrasonic waves).

[0046] Such as formula (1), σ 0 is the original resistivity, Δσ is the change of tissue resistivity caused by the change of ultrasonic sound pressure ΔP, k is the acoustic-electric interaction coefficient, for example, the acoustic-electric interaction coefficient in rabbit heart tissue is 0.041±0.012% MPa-1.

[0047] Δσ = kσ 0 ΔP (1)

[0048] The acoustoelectric effect shows that tissue resistivity modulation is most pronounced in the focused region of the ultras...

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Abstract

The invention discloses a 4D transcranial focused ultrasonic neuroimaging method based on an acoustoelectric effect. The method includes the steps that a focused ultrasonic signal generator and an energy converter are adopted to achieve generation and emission of focused ultrasonic signals, and focused ultrasonic characteristics under different parameters are determined; an electroneurographic signal collecting device composed of an electroencephalogram collecting system provided with an electroencephalogram electrode, an electroencephalogram amplifier and an electroencephalogram filter and anelectroneurographic-signal measuring system based on ultrasonic modulation is installed and connected; ultrasonic waves are spread through the cranium and focused on a certain position, and based onthe acoustoelectric effect principle, scalp electroencephalogram signals after ultrasonic modulation, namely, acoustoelectric signals are collected; through the amplitude values, the frequency and thephase position relevance of the acoustoelectric signals and activation source signals, the electroencephalogram signals are subjected to spatial encoding and demodulation, 4D neuroimaging of high space-time resolution is achieved, and multiple requirements in practical application are met.

Description

technical field [0001] The invention relates to the technical field of nerve function imaging, in particular to a 4D transcranial focused ultrasound neuroimaging method based on an acoustoelectric effect. Background technique [0002] Neuroimaging refers to techniques capable of directly or indirectly imaging the functional, structural, and pharmacological properties of the nervous system (mainly the brain). Neuroimaging is divided into structural imaging and functional imaging, among which neurofunctional imaging is mainly used in neuroscience and psychology research, and is gradually becoming a new way of medical neurological diagnosis recently. [0003] In the existing neurofunctional imaging technology, EEG (electroencephalography) is a synthetic signal of synchronous post-synaptic potential generated by neuron clusters when recording brain activity, which is the overall reflection of the neurophysiological activity of the cerebral cortex, and has been widely used in cli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/053A61B5/0476A61B8/00
CPCA61B5/0536A61B8/00A61B5/369
Inventor 明东周伊婕宋西姊赵学陈新瑞何峰
Owner TIANJIN UNIV
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