Maltose functionalized nanocomposite material based on ion-complementary peptide self-assembly and its preparation method and application
A nanocomposite material and nanomaterial technology, applied in the field of maltose functionalized nanocomposite materials, can solve problems such as harsh conditions, cumbersome processing steps, and strong surface dependence, and achieve mild conditions, environmentally friendly process, and simple preparation methods Effect
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Embodiment 1
[0039] 1. Synthesis of maltose-modified ion-complementary peptides
[0040] (1) Add 0.174g Fmoc-Rink Amide MBHA Resin to the solid phase synthesis tube, add 5mL of dichloromethane to soak the resin for 30 minutes, fully swell, remove the dichloromethane by suction filtration, add 5mL of piperidine and N to the solid phase synthesis tube , the volume ratio of N-dimethylformamide is a mixed solution of 1:4, reacted for 20 minutes, the mixed solution was removed by suction filtration, and the volume ratio of adding 5mL piperidine and N,N-dimethylformamide was 1: The mixture of 4 was reacted for 20 minutes, filtered with suction, and the resin was washed twice with dichloromethane and 3 times with N,N-dimethylformamide, each 5 mL, to complete the removal of Fmoc-Rink Amide MBHA Resin from Fmoc-Rink Amide MBHA Resin. time, and then add 5mL N,N-dimethylformamide, 0.1331g Fmoc-Lys(Boc)-OH, 0.03837g 1-hydroxybenzotriazole, 0.1077g benzotriazole-N,N,N′ ,N'-tetramethylurea tetrafluorob...
Embodiment 2
[0053] In this example, C@Fe is used 3 O 4 Nanoparticles (prepared according to the method disclosed in the literature "Yang, J.; Li, J.; Qiao, J.; Lian, H.; Chen, H.J. Chromatogr. A 2014, 1325, 8-15") were replaced and implemented SiO in Example 1 2 @Fe 3 O 4 Nanoparticles, other steps are the same as in Example 1 to obtain maltose-functionalized C@Fe 3 O 4 composite material.
[0054] The Fe in the above-mentioned Examples 1 and 2 was 3 O 4 , SiO 2 @Fe 3 O 4 , C@Fe 3 O 4 , Maltose functionalized SiO 2 @Fe 3 O 4 Composites and Maltose-functionalized C@Fe 3 O 4 The composite materials were subjected to Fourier transform attenuated total reflection infrared spectroscopy and X-ray photoelectron spectroscopy, and the results were as follows Figure 2 to Figure 6 shown. It can be seen from the figure that the maltose functionalized SiO 2 @Fe 3 O 4 Composites and Maltose-functionalized C@Fe 3 O 4 Composite (580cm -1 At Fe-O, 1100cm -1 Si-O-Si at 1740 and 1...
Embodiment 3
[0056] Application of Maltose-functionalized Nanocomposites Obtained in Examples 1 and 2 in Glycopeptide Enrichment
[0057] 1. Comparative experiment of enrichment performance of different materials
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