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Pathogen infection injury mechanism analysis method and device thereof

A pathogen infection and mechanism technology, applied in the field of genetic data processing, can solve time-consuming and labor-intensive problems, achieve accurate analysis, reduce experimental errors, and reduce R&D costs

Active Publication Date: 2019-04-23
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003]A method and device for analyzing the damage mechanism of pathogen infection provided by the embodiment of the present invention can solve the time-consuming problem existing in the prior art when analyzing the damage mechanism of unknown pathogen infection strenuous technical problems

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  • Pathogen infection injury mechanism analysis method and device thereof
  • Pathogen infection injury mechanism analysis method and device thereof
  • Pathogen infection injury mechanism analysis method and device thereof

Examples

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no. 1 example

[0024] see figure 1 , is a flow chart of the method for analyzing the damage mechanism of pathogen infection provided by the first embodiment of the present invention. The following will be figure 1 The specific process shown will be described in detail.

[0025] Step S101, obtaining the genome-wide expression data after multiple gene silencing.

[0026] As an embodiment, a large amount of genome-wide expression data after gene silencing is obtained from the LINCS (The Library of Integrated Network-based Cellular Signatures, network-based cell characteristic library) database.

[0027] Optionally, after obtaining the genome-wide expression data, data preprocessing is performed on the genome-wide expression data by reducing batch effects and selecting credible representatives. For example, by reducing the error caused by the batch effect, the data structure adopted by the LINCS plan is divided into four levels (Level) of data, Level 1 data records the fluorescence values ​​o...

no. 2 example

[0051] Corresponding to the photographing method in the first embodiment, figure 2 It shows a one-to-one correspondence analysis device for pathogen infection damage mechanism using the pathogen infection damage mechanism analysis method shown in the first embodiment. Such as figure 2 As shown, the pathogen infection damage mechanism analysis device 400 includes a first acquisition unit 410 , a first processing unit 420 , a second acquisition unit 430 , a second processing unit 440 , a third acquisition unit 450 and a fourth processing unit 460 . Among them, the implementation functions of the first acquisition unit 410, the first processing unit 420, the second acquisition unit 430, the second processing unit 440, the third acquisition unit 450 and the fourth processing unit 460 are similar to the corresponding steps in the first embodiment. One-to-one correspondence, in order to avoid redundant description, this embodiment does not describe in detail one by one.

[0052]...

no. 3 example

[0064] Such as image 3As shown, is a schematic diagram of an electronic device 300 . The electronic device 300 includes a memory 302, a processor 304, and a computer program 303 stored in the memory 302 and operable on the processor 304. When the computer program 303 is executed by the processor 304, the first embodiment is realized. In order to avoid repetition, the method for analyzing the mechanism of pathogen infection and damage described in the example will not be repeated here. Alternatively, when the computer program 303 is executed by the processor 304, the functions of each module / unit in the apparatus for analyzing the mechanism of pathogen infection and damage described in the second embodiment are implemented. To avoid repetition, details are not repeated here.

[0065] Exemplarily, the computer program 303 can be divided into one or more modules / units, and one or more modules / units are stored in the memory 302 and executed by the processor 304 to implement the ...

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Abstract

An embodiment of the invention provides a pathogen infection injury mechanism analysis method and a device thereof, wherein the method and the device belong to the field of gene data processing. The method comprises the steps of acquiring full-genome expression data after silencing of a plurality of genes; obtaining a gene expression order row which corresponds with the full-genome expression data; acquiring the full-genome expression spectrum data after infection of a plurality of different pathogens; constructing an imprinting gene set which is infected by the pathogen based on the full-genome expression spectrum data; acquiring enrichment scores of the gene expression order sequence and the imprinting gene set; and determining the pathogen infection injury mechanism based on the enrichment scores, thereby combining mass various cross-platform transcriptome big data, realizing no requirement for pathogen culturing from the beginning or cell infection or large-scale experiment, further reducing development cost and shortening detecting period. Furthermore experiment errors are reduced so that higher accuracy in analyzing the pathogen infection injury mechanism is realized.

Description

technical field [0001] The invention relates to the field of gene data processing, in particular to a method and device for analyzing the mechanism of pathogen infection and damage. Background technique [0002] At present, the existing differentially expressed gene analysis analyzes the gene expression difference caused by unknown pathogen infection, and then analyzes the damage mechanism of unknown pathogen infection by targeting the gene with the largest differential expression fold change. Experiments are time-consuming and labor-intensive, and the analysis of a single gene may miss some important pathways, or there are only a few replicates of differentially expressed genes obtained by different research institutions on the same biological system. Contents of the invention [0003] The method and device for analyzing the damage mechanism of pathogen infection provided by the embodiments of the present invention can solve the technical problem of time-consuming and lab...

Claims

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Application Information

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IPC IPC(8): G16B25/10
CPCY02A90/10
Inventor 伯晓晨何松文昱琦宋欣雨刘祯杨晓曦
Owner ACADEMY OF MILITARY MEDICAL SCI
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