Transdermal liniment for preventing and treating yak parasitosis and preparation method of transdermal liniment

A parasitic disease and transdermal technology, which is applied in the field of transdermal liniment for the prevention and treatment of yak parasitic diseases and its preparation, can solve economic losses, inconvenient drug administration methods for herdsmen, and poor treatment of yak parasitic diseases control and other problems, to achieve the effect of convenient administration and drug efficacy

Inactive Publication Date: 2019-04-26
TIBET AGRI & ANIMAL HUSBANDRY COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the traditional methods of oral administration and injection are still used for the prevention and treatment of yak parasitic diseases. Due to the wildness of yaks and the low awareness of prevention and control of herdsmen, and the inconvenient control of traditional drug administration methods, yak parasitic diseases cannot be well treated. control, resulting in huge economic losses

Method used

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  • Transdermal liniment for preventing and treating yak parasitosis and preparation method of transdermal liniment

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Formula ingredients: Azone 3%, oleic acid 3%, propylene glycol 11%, dimethyl sulfoxide 5%, ethylene glycol phenyl ether 78% (volume ratio), praziquantel 300mg / mL, 10mL / bottle.

[0026] Preparation method: Manually stir in a 60°C water bath until completely dissolved to obtain a transdermal liniment.

[0027] Detect the solubility and transdermal property of the transdermal liniment, and calculate the comprehensive effect according to the following formula:

[0028] Comprehensive effect = solubility × transdermal property

[0029] The test results are: the solubility is 358mg / mL; the transdermal property is 19.9mg / 100mg; the comprehensive effect is 71.24mg / mL. Among them, the higher the comprehensive effect, the better the comprehensive performance of skin penetration and solubility, which is more conducive to the exertion of the drug effect.

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Abstract

The invention provides a transdermal liniment for preventing and treating yak parasitosis, and belongs to the field of veterinary drugs. The transdermal liniment is prepared from praziquantel and an excipient; the mass volume ratio of the praziquantel to the excipient is (200 to 400 mg) to 1 mL; the excipient is prepared from the following raw materials in percentage by volume: 3 percent of azone,3 percent of oleic acid, 11 percent of propylene glycol, 5 percent of dimethyl sulfoxide and 78 percent of ethylene glycol monophenyl ether. The transdermal liniment disclosed by the invention overcomes the defects of poor solubility and poor transdermal effect of the praziquantel through reasonable matching; in addition, the transdermal liniment disclosed by the invention is convenient for administration and can effectively play the efficacy of drugs.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a transdermal liniment for preventing and treating yak parasitic diseases and a preparation method thereof. Background technique [0002] Yak is a pillar industry for the economic development of alpine grasslands in the Qinghai-Tibet Plateau, and it is one of the unique livestock species on the Qinghai-Tibet Plateau. There are nearly 14 million yaks in my country, mainly distributed in Qinghai, Tibet, Sichuan, Gansu and other provinces. As the main animal species of plateau grassland animal husbandry, yak has an irreplaceable position in Tibet's animal husbandry production. The steady, healthy and sustainable development of the yak industry plays an important role in the economic development of the entire Tibetan area. [0003] At present, yaks are still mainly grazing traditionally. Parasitic diseases are one of the most serious diseases that endanger yak production at prese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/4985A61K47/22A61K47/12A61K47/10A61K47/20A61P33/10
CPCA61K9/0014A61K31/4985A61K47/10A61K47/12A61K47/20A61K47/22A61P33/10
Inventor 李家奎高兴张丽鸿参木有罗晓林石红梅索朗斯珠
Owner TIBET AGRI & ANIMAL HUSBANDRY COLLEGE
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