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Synergistic antifungal compositions and methods thereof

A composition, antifungal technology, applied in the field of antimicrobial agents and pharmaceutical sciences, can solve the problem of high recurrence rate

Inactive Publication Date: 2019-04-26
VYOME THERAPEUTICS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the use of said product, the relapse rate is higher

Method used

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  • Synergistic antifungal compositions and methods thereof
  • Synergistic antifungal compositions and methods thereof
  • Synergistic antifungal compositions and methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0264] Example 1: Medium-chain fatty acid / esters (C-1 to C- 14) Exemplary synergistic antifungal combinations with multiple antifungal agents

[0265] Using the above checkerboard layout protocol ( Figure 1A ), testing the ability of various medium chain fatty acids to enhance the activity of known antifungal agents. Concentrations of each test agent above and below its MIC were tested using serial dilutions. The same procedure was extended to test various medium chain fatty acids C-1 to C-14 (such as caprylic acid, undecylenic acid and lauric acid) against susceptible and resistant Trichophyton (filamentous fungus) and Candida (yeast). ) and esters thereof in combination with antifungal agents from various classes including azoles, allylamines, benzylamines, zinc pyrithione and piroctone olamine.

[0266] method : The enhancement of antifungal activity using ester derivatives of medium chain fatty acids was tested in a standard recognized in vitro assay system to dete...

Embodiment 2

[0305] Embodiment 2: the preparation of the various oil compositions containing piroctone olamine and octanoic acid

[0306] Compositions are prepared by dissolving the active agent in ethanol or isopropanol (IPA). Then, oleyl alcohol was added and stirred until a homogeneous solution was obtained. In addition to liquid paraffin, other excipients or additives are added and stirred to obtain a clear solution. Finally, make up to weight with liquid paraffin and stir until a homogeneous solution is obtained. The final formulation is a clear transparent oil solution. "Table 15" describes clear antifungal oil compositions containing piroctone olamine and medium chain fatty acids and / or esters as antifungal agents using various excipients or additives.

[0307] Table 15: Piroctone olamine-caprylic acid-oil composition

[0308]

[0309]

[0310] C-clear, ST-slightly cloudy, PO-piroctone olamine, IPA-isopropanol, OA-oleyl alcohol, Cap.A-caprylic acid, Toco.Ace-tocopheryl...

Embodiment 3

[0314] Embodiment 3: the preparation of the various oil compositions containing ketoconazole and octanoic acid

[0315] Compositions are prepared by dissolving the active agent in ethanol. Then, oleyl alcohol was added and stirred until a homogeneous solution was obtained. In addition to liquid paraffin, other excipients or additives are added and stirred to obtain a clear solution. Finally, make up to weight with liquid paraffin and stir until a homogeneous solution is obtained. The final formulation is a clear transparent oil solution. "Table 16" describes clear antifungal oil compositions containing ketoconazole and medium chain fatty acids and / or esters as antifungal agents using various excipients or additives.

[0316] Table 16: Ketoconazole-octanoic acid-oil compositions

[0317]

[0318] C-clear and transparent, ST-slightly turbid

[0319] result:

[0320] 1. Compositions containing ketoconazole and medium-chain fatty acids and / or esters and other excipien...

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Abstract

The present invention relates to the field of antimicrobials and pharmaceutical sciences. The invention provides antifungal compositions for the management of fungal growth and treatment of fungal infections, including treatment of resistant fungal infections. The present compositions comprise at least one antifungal agent and at least one medium-chain saturated or unsaturated fatty acid having carbon chain length of C-1 to C-14 or ester thereof, optionally along with excipient(s), giving rise to a synergistic antifungal activity.

Description

technical field [0001] The present invention relates to the fields of antimicrobial agents and pharmaceutical sciences. The present invention provides antifungal compositions for managing fungal growth and treating fungal infections, including treating resistant fungal infections. The compositions of the present invention comprise an antifungal agent and medium chain saturated or unsaturated fatty acids or esters thereof, optionally together with excipients, resulting in a synergistic antifungal activity. Background technique [0002] Fungal infections of the skin are also known as "mycoses". It is common and usually mild. However, fungi can sometimes cause serious disease in diseased or otherwise immunosuppressed individuals. Fungal infections in humans range from superficial (ie skin surface) types to deeply invasive or disseminated infections. [0003] Typically, superficial fungal infections (also known as dermatophytosis) can affect the outer layer of skin, nails, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K31/137A61K31/19A61K31/20A61K31/201A61K31/343A61K31/407A61K31/4164A61K31/4174A61K31/4178A61K31/4196A61K31/422A61K31/496A61K31/506A61K31/513
CPCA61K31/122A61K31/137A61K31/19A61K31/20A61K31/201A61K31/23A61K31/231A61K31/343A61K31/407A61K31/4164A61K31/4174A61K31/4178A61K31/4196A61K31/422A61K31/496A61K31/506A61K31/513A61K31/5375A61K31/69A61K31/7032A61K31/7034A61P31/10A61K31/4015A61K45/06A61P17/00A61K9/0014A61K47/12A61K47/14A61K47/06A61Q17/005A61K8/361A61K8/355A61K8/411A61K8/41A61K8/37A61K2300/00A61K31/215A61K31/555
Inventor 沙米克·高希苏马纳·高希毛·辛哈苏雷什·萨达西瓦姆阿努布胡蒂·贾殷阿纳米卡·巴塔查里亚
Owner VYOME THERAPEUTICS LTD
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