Modified polyethylene glycol-poly glyceride sebacate (PEGS) injectable biological elastomer as well as preparation method and application thereof

A polyethylene glycol and elastomer technology, which is used in the field of material science and medicine, and can solve the problems of complex cross-linking conditions of polyglycerol sebacate, poor hydrophilicity, and limited soft tissue performance.

Active Publication Date: 2019-05-03
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the complex cross-linking conditions of polyglyceryl sebacate and its poor hydrophilicity after molding, its use in soft tissues is limited, and it cannot be used to load biologically active factors such as proteins or drugs, and it needs to be modified before application

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  • Modified polyethylene glycol-poly glyceride sebacate (PEGS) injectable biological elastomer as well as preparation method and application thereof
  • Modified polyethylene glycol-poly glyceride sebacate (PEGS) injectable biological elastomer as well as preparation method and application thereof
  • Modified polyethylene glycol-poly glyceride sebacate (PEGS) injectable biological elastomer as well as preparation method and application thereof

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preparation example Construction

[0095] In a specific embodiment, the present invention provides a preparation method of the bioelastomer, the preparation method comprising the following steps:

[0096] (i) preparation of polyglyceryl sebacate and polyethylene glycol-polyglyceryl sebacate prepolymer;

[0097] (ii) polyglyceryl sebacate and polyethylene glycol-polyglyceryl sebacate prepolymer react with mercaptocystamine salt in a solvent, and its solvent addition is 10~15 times of high molecular weight, its N,N-dimethylamide is used in the solvent experiment stage, and ethanol, ether, tetrahydrofuran, etc. can be used in the subsequent stage.

[0098] In a specific embodiment, the present invention provides a method for preparing the bioelastomer, comprising the steps of:

[0099] (a) Dissolve the dried prepolymer in anhydrous N,N-dimethylamide (such as 100ml), preferably, the solution concentration is 0.05~0.1g / ml (such as 0.1g / ml );

[0100] (b) 3-aminopropyltrimethoxysilane coupling agent with a molar r...

Embodiment 1

[0121] The synthesis of embodiment 1 bioelastomer material

[0122] (1) Preparation of bioelastomer linear oligomers:

[0123] (a) Dry the instrument in an oven at 50°C, then set up the experimental device, feed argon, and mix sebacic acid and polyethylene glycol (the number average molecular weight of polyethylene glycol is 600- 3000g / mol) at 125-135°C for 1.5-3.5 hours;

[0124] (b) placing the product in step (a) at 125-135° C. and reacting under vacuum conditions for 24 hours to obtain a linear prepolymer of sebacic acid-polyethylene glycol;

[0125] (c) under an argon atmosphere, add sebacic acid and glycerol to the linear prepolymer of sebacic acid-polyethylene glycol obtained in step (b) (step (c) sebacic acid: glycerol: step (a ) used sebacic acid=0.5:1.16:1, based on the amount of substance), and reacted for 40-60 hours at 125-135° C. under vacuum conditions to obtain crude polyethylene glycol-polyglyceryl sebacate prepolymer ;

[0126] (d) purifying the crude p...

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Abstract

The invention discloses a modified polyethylene glycol-poly glyceride sebacate (PEGS) injectable biological elastomer as well as preparation and application thereof, wherein the modified polyethyleneglycol-poly (sebacic acid) (PEGS) injectable biological elastomer can be in-situ cured at body temperature. The biological elastomer is obtained by taking polyethylene glycol-poly glyceride sebacate (PEGS) as a matrix, and respectively performing sulfhydrylation and acrylation reaction on hydroxyl groups of the main chain or the side chain of the matrix, two modified PEGS can be mixed and then injected into a body and cured at the body temperature. The mechanical strength, hydrophilicity and hydrophobicity, degradation behavior, cell behavior and biocompatibility of the biological elastomer can be regulated and optimized through the content of polyethylene glycol and the proportion of carboxyl hydroxyl. The biological elastomer can be successfully prepared into injectable hydrogel materials for bone repair and tissue regeneration. The research results show that the modified polyethylene glycol-poly glyceride sebacate (PEGS) injectable biological elastomer is a tissue repair material with a very wide clinical application prospect.

Description

technical field [0001] The invention is in the field of material science and medicine, and specifically relates to the preparation and application of a bioelastic material that can be cured in situ at body temperature. Background technique [0002] Since Professor Robert Langer of MIT and Professor Joseph Vacanti of Harvard University put forward the concept of tissue engineering in the 1980s, biological materials as the carrier of this interdisciplinary subject have developed rapidly. Due to the elasticity of soft tissues such as skin, blood vessels, heart, etc., and with the advancement of tissue engineering technology, people have higher and higher requirements for repair materials. Due to its excellent flexibility, viscoelasticity and mechanical properties similar to the surrounding tissue, bioelastomer materials have attracted great attention in biomedical applications. Among them, hydrogels can be used because of their excellent structure. Designability and biocompati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00A61L29/06A61K47/34C12N5/00
Inventor 袁媛王佳琪吴怡清顾雨冬金抒晗孙丽丽
Owner EAST CHINA UNIV OF SCI & TECH
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