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Moisturizing and lubricating composition containing xanthan gum and application thereof

A composition, xanthan gum technology, applied in the directions of organic cleaning compositions, detergent compositions, surface active detergent compositions, etc., can solve the problems of high production cost, poor stability, dry skin, etc. The effect of avoiding the reduction of lubricity and improving the lubricating and moisturizing effect

Active Publication Date: 2019-05-07
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Each moisturizing lubricant has certain advantages and disadvantages: PCA is a moisturizing factor naturally present in the skin, and its moisturizing and hygroscopicity are significantly better than glycerin, propylene glycol, and sorbitol. When the air humidity is low, it makes the skin more dry
Although sodium hyaluronate has good water absorption and moisturizing properties, its production cost is relatively high, and there are many factors affecting moisturizing and lubricating properties, such as pH enzymes, reducing substances, ultraviolet rays, etc., and its stability is very poor. And the difference in manufacturing technology has a significant impact on the effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A composition with moisturizing and lubricating properties, comprising the following components and proportions: 0.1% xanthan gum (Mw=1 million), 0.0001% PHMB, 0.05% poloxamer 407, 0.02% EDTA-2Na, boric acid Salt buffer (pH 7.4) was added to 100mL, and NaCl was added to adjust the osmotic pressure of the care solution to be 290mOsm / (Kg·H 2 O). Wherein, the water used is water for injection.

Embodiment 2

[0034] A composition with moisturizing and lubricating properties, comprising the following components and proportions: 0.5% xanthan gum (Mw=1 million), 0.0001% PHMB, 0.05% poloxamer 407, 0.02% EDTA-2Na, boric acid Salt buffer (pH 7.4) was added to 100mL, and NaCl was added to adjust the osmotic pressure of the care solution to be 290mOsm / (Kg·H 2 O). Wherein, the water used is water for injection.

Embodiment 3

[0036] A composition with moisturizing and lubricating properties, comprising the following components and proportions: 1.0% xanthan gum (Mw=1 million), 0.0001% PHMB, 0.05% poloxamer 407, 0.02% EDTA-2Na, boric acid Salt buffer (pH 7.4) was added to 100mL, and NaCl was added to adjust the osmotic pressure of the care solution to be 290mOsm / (Kg·H 2 O). Wherein, the water used is water for injection.

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PUM

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Abstract

The invention provides a moisturizing and lubricating composition containing xanthan gum, the moisturizing and lubricating composition comprises the following components in percentage by mass: 0.005%-2.5% of the xanthan gum, 0.005%-15% of a buffering agent, 0.0005%-10% of a surfactant, 0.0005%-5% of a chelating agent, 0.00005%-0.005% of a bacteriostatic agent, 0.005%-5% of an osmotic pressure regulator, and the balance of water for injection; and the composition can be used for treating contact lenses to serve as a contact lens care solution. The composition takes the xanthan gum with the certain mass fraction and molecular weight as a moisturizing lubricant can show excellent lubrication and moisturizing properties, the abrasion between the contact lens which is treated by using the composition and cornea can be reduced, the wearing comfort degree and the moisture-maintaining humidity can be improved, meanwhile, compared with a nursing solution taking hyaluronic acid as a lubricant, the composition shows a better moisturizing and lubricating effect.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a moisturizing and lubricating composition containing xanthan gum and an application thereof. Background technique [0002] With the popularity of contact lenses, various types of contact lens care solutions have been launched one after another. Their basic functions are to clean, disinfect and remove protein from contact lenses. But the main aspect that affects the wearer's experience is moisturizing and lubricity. Insufficient moisture retention will cause insufficient liquid filling between the cornea and contact lens, and insufficient lubricity will increase the friction between the lens and the ocular surface. Therefore, after wearing lenses, users are prone to problems such as dry eyes, corneal damage and inflammation. Currently commonly used moisturizing and lubricating factors mainly include hyaluronic acid (HA), sodium pyrrolidone carboxylate (PCA), polyvinyl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D1/722C11D3/60C11D3/48C11D3/37C11D3/33C11D3/04
CPCC11D1/722C11D3/04C11D3/33C11D3/37C11D3/48
Inventor 凌沛学邵新田边玲
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES