Application of pharmaceutical composition containing hydroxyurea

Abstract

The present invention provides an application of a pharmaceutical composition containing hydroxyurea, and hydroxyurea or pharmaceutically acceptable salts thereof are used for preparation of medicinesfor preventing and / or treating atherosclerosis. The results of an experiment show that after oral administration of combination of hydroxyurea, aspirin and clopidogrel hydrogen sulfate, aortic intimafat and porridge-like lesion regions are significantly reduced, the drug effect on atherosclerosis is obvious (plaque inhibition degree 85%), the concentration of blood glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol is decreased, and glycolipid metabolism disorder is significantly improved; after oral administration of combination of hydroxyurea, aspirin, clopidogrel hydrogen sulfate and atorvastatin calcium, aortic intima fat and porridge-like lesion regions are significantly reduced, and atherosclerosis is essentially cured (plaque inhibition degree 91%). Thecombination of drugs at this dose has an outstanding therapeutic effect in the prevention and / or treatment of atherosclerosis.

Description

[0001] This application claims the priority of the Chinese patent application submitted to the China Patent Office on January 23, 2019, with the application number 201910063116.2, and the title of the invention is "A Hydroxyurea and Its Salts and Applications of Pharmaceutical Compositions Including It" , the entire contents of which are incorporated in this application by reference. technical field [0002] The invention belongs to the technical field of medicine, and in particular relates to the application of a pharmaceutical composition comprising hydroxyurea or a salt thereof. Background technique [0003] With the development of the economy and the improvement of people's living standards, cardiovascular disease has become the number one killer of human beings, and as the common pathological basis of cardiovascular and cerebrovascular diseases such as coronary heart disease, cerebral infarction, and peripheral vascular disease, atherosclerosis is seriously harmful It a...

AI Technical Summary

Problems solved by technology

Due to the complexity of the etiology of atherosclerosis, the current clinical treatment options are still very limited

When the drug effect of single administration reaches a certain level, it is very difficult to combine other drugs to enhance the drug effect, such as the combination of oral aspirin and clopidogrel bisulfate, or oral administration of atorvastatin calcium alone, atherosclerotic plaque The area can all show a certain degree of reduction (less than or about 50%), and when the three drugs are used in combination, the curative effect is only increased by about 10% compared with the previous two drugs in combination, and the curative effect has basically reached the plateau stage. additive effect

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