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Application of D-mannose in preparation of product for resisting dopamine reduction and/or improving dopamine level

A technology of dopamine and mannose, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, nervous system diseases, etc., can solve problems that have not caused researchers to achieve the effect of treating Parkinson's disease, improving the level, and restoring function

Inactive Publication Date: 2019-05-31
SHANDONG UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The level of D-mannose in human blood is less than 1 / 5 of that of glucose, which has not attracted the attention of researchers in previous studies

Method used

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  • Application of D-mannose in preparation of product for resisting dopamine reduction and/or improving dopamine level
  • Application of D-mannose in preparation of product for resisting dopamine reduction and/or improving dopamine level
  • Application of D-mannose in preparation of product for resisting dopamine reduction and/or improving dopamine level

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Embodiment 1

[0047] 1. Experimental materials and methods

[0048] (1) Experimental mice C57BL / J, 4-6 weeks old, male; divided into stress group and non-stress group, normal drinking water group and mannose drinking water group, 10 mice in each group.

[0049] (2) Adopt chronic restraint stress model: restraint stress for 4-6 hours every morning, fasting for three weeks.

[0050] (3) Drinking water: the normal drinking water group drank ordinary drinking water, and the mannose drinking water group drank mannose water with a concentration of 25 mM.

[0051] (4) Three weeks later, the mice were removed from the eyeballs to take blood, and the brain regions of the hippocampus, hypothalamus and prefrontal cortex of the mouse brain were separated, and the protein was precipitated with perchloric acid, and the supernatant was taken to detect neurotransmitters in different brain regions by high performance liquid chromatography Dopamine (DA) content, test results are attached Figure 1-3 shown....

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Abstract

The invention relates to application of D-mannose in preparation of a product for resisting dopamine reduction and / or improving the dopamine level. A chronic restraint stress model is utilized to damage mouse dopaminergic neurons ((as described in the description) no restraint stress, CRS chronic restraint stress) and find that D-mannose is resistant resist reduction of mice hippocampus, hypothalamic and prefrontal dopamine, so that dopaminergic neuron loss can be resisted, the degradation of dopamine in the hypothalamus (MAO-B) can be restrained, the dopamine level is increased, and the dopaminergic neuron functions are restored.

Description

technical field [0001] The disclosure belongs to the field of biotechnology, and specifically relates to the application of D-mannose in the preparation of products resisting the reduction of dopamine and / or increasing the level of dopamine. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Dopamine (DA) is a neurotransmitter, a chemical used to help cells transmit impulses. This brain secretion is related to human desire and feeling, and it conveys information of excitement and happiness. As a kind of excitatory neurotransmitter, dopamine is not only a hormone in the catechol ethylamine family, but also plays an important role in human metabolism, cardiovascular, kidney, ...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61P25/16
Inventor 张利宁李艳贾玉峰李媛陈诺王群朱法良郭春
Owner SHANDONG UNIV
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