Environmentally friendly medical hot-melt pressure-sensitive adhesive and preparation method thereof

A hot-melt pressure-sensitive adhesive, environmentally friendly technology, applied in the direction of epoxy resin glue, adhesive, adhesive type, etc., can solve the problems of unfavorable dissolution and release of non-polar drugs, complicated use process, low drug loading, etc. Achieve the effect of benefiting drug development, high drug loading, enhanced chemical stability and high temperature resistance

Inactive Publication Date: 2019-05-31
广州齐博医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hot-melt pressure-sensitive adhesive prepared by this method can only facilitate the dissolution and release of polar drugs, and is not conducive

Method used

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  • Environmentally friendly medical hot-melt pressure-sensitive adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0033] Example 1

[0034] An environmentally friendly medical hot-melt pressure-sensitive adhesive, which is made of the following parts by weight of raw materials: 55 parts of styrene-isoprene-styrene thermoplastic elastomer, 35 parts of modified acrylic resin, 25 parts of mixed rubber, 3 parts Dibutyl hydroxytoluene, 5 parts rosin, 50 parts deionized water, 35 parts white oil;

[0035] The environmentally friendly medical hot melt pressure sensitive adhesive is made by the following steps:

[0036] Step S1. Mix the styrene-isoprene-styrene thermoplastic elastomer and the modified acrylic resin into the internal mixer, control the roll distance to 3.5mm, the temperature is 80°C, and add dibutylhydroxyl after stirring for 30min Toluene, heated to 150°C and compacted for 45 minutes to obtain a mixture;

[0037] Step S2. Add the mixed rubber and rosin into a three-necked flask, add deionized water and white oil, soak for 5 hours, then pass in nitrogen, heat to 120°C, keep it for 3 hour...

Example Embodiment

[0047] Example 2

[0048] An environmentally friendly medical hot-melt pressure-sensitive adhesive, made of the following parts by weight: 60 parts of styrene-isoprene-styrene thermoplastic elastomer, 40 parts of modified acrylic resin, 30 parts of mixed rubber, 5 parts Dibutyl hydroxytoluene, 7 parts rosin, 53 parts deionized water, 40 parts white oil;

[0049] The environmentally friendly medical hot melt pressure sensitive adhesive is made by the following steps:

[0050] Step S1. Mix the styrene-isoprene-styrene thermoplastic elastomer and the modified acrylic resin into the internal mixer, control the roll distance to 3.5mm, the temperature is 80°C, and add dibutylhydroxyl after stirring for 30min Toluene, heated to 150°C and compacted for 45 minutes to obtain a mixture;

[0051] Step S2. Add the mixed rubber and rosin into a three-necked flask, add deionized water and white oil, soak for 5 hours, then pass in nitrogen, heat to 120°C, keep it for 3 hours, stir at 200r / min, and t...

Example Embodiment

[0053] Example 3

[0054] An environmentally friendly medical hot-melt pressure-sensitive adhesive, made of the following parts by weight of raw materials: 65 parts styrene-isoprene-styrene thermoplastic elastomer, 50 parts modified acrylic resin, 40 parts mixed rubber, 7 parts Dibutyl hydroxytoluene, 8 parts rosin, 58 parts deionized water, 45 parts white oil;

[0055] The environmentally friendly medical hot melt pressure sensitive adhesive is made by the following steps:

[0056] Step S1. Mix the styrene-isoprene-styrene thermoplastic elastomer and the modified acrylic resin into the internal mixer, control the roll distance to 3.5mm, the temperature is 80°C, and add dibutylhydroxyl after stirring for 30min Toluene, heated to 150°C and compacted for 45 minutes to obtain a mixture;

[0057] Step S2. Add the mixed rubber and rosin into a three-necked flask, add deionized water and white oil, soak for 5 hours, then pass in nitrogen, heat to 120°C, keep it for 3 hours, stir at 200r / mi...

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Abstract

The invention discloses an environmentally friendly medical hot-melt pressure-sensitive adhesive, which is prepared from following raw materials in parts by weight: 55 to 70 parts of styrene-isoprene-styrene thermoplastic elastomer, 35 to 55 parts of modified acrylic resin, 25 to 45 parts of mixed rubber, 3 to 8 parts of antioxidant, 5 to 10 parts of tackifier, 50 to 60 parts of deionized water, and 35 to 50 parts of white oil. The invention also discloses a preparation method of the environmentally friendly medical hot-melt pressure-sensitive adhesive. Styrene-isoprene-styrene thermoplastic elastomer, modified acrylic resin, and mixed rubber are taken as raw materials to prepare the hot-melt pressure-sensitive adhesive; the styrene-isoprene-styrene hot-melt pressure-sensitive adhesive hasthe advantages of good cohesive force, small irritation, and high drug loading capacity, and is a good drug carrier matrix of a percutaneous patch; and the prepared environmentally friendly medical hot-melt pressure-sensitive adhesive can provide release channels for drugs with different polarities, has a stable property, and assists the action of drugs.

Description

technical field [0001] The invention belongs to the technical field of synthetic adhesives, in particular to an environment-friendly medical hot-melt pressure-sensitive adhesive and a preparation method thereof. Background technique [0002] Hot-melt pressure-sensitive adhesive has thermoplastic processability. It can be mixed and coated in the molten state. After cooling and solidification, light finger pressure can be applied to quickly bond, and at the same time it can be easily peeled off without polluting the adherend. surface. Hot-melt pressure-sensitive adhesives are environmentally friendly, environmentally friendly, and can improve production safety. Styrene-isoprene-styrene hot-melt pressure-sensitive adhesive has good cohesion, low irritation and high drug loading capacity, and has been used as a drug-loading matrix for transdermal patches. [0003] Physically blending modified polymer materials is an effective way to improve the comprehensive performance of pol...

Claims

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Application Information

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IPC IPC(8): C09J153/02C09J133/12C09J183/07C09J183/04C09J127/12C09J163/00C09J11/06C09J11/08C09J11/04C08F8/14C08F220/14
Inventor 徐静舒艳婷
Owner 广州齐博医疗科技有限公司
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