Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of preparation method of cefuroxime sodium crystal form compound

A technology of cefuroxime sodium and furoxin sodium crystals, which is applied in the field of medicine, can solve problems such as difficult removal, high cost of cyclohexanol, and solvent residue, and achieve the effects of low moisture absorption, stability advantages, and mild conditions

Active Publication Date: 2022-04-12
GUANGZHOU BAIYUSN TIANXIN PHARMA
View PDF12 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cyclohexanol used in this method is expensive, difficult to remove, and solvent residue is a problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of cefuroxime sodium crystal form compound
  • A kind of preparation method of cefuroxime sodium crystal form compound
  • A kind of preparation method of cefuroxime sodium crystal form compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 cefuroxime sodium crystal form compound

[0023] Disperse 10 g of cefuroxime sodium in 50 ml of 98% ethanol, heat to 45°C, stir for 2 hours, filter while hot, and dry in vacuum at 40°C for 4 hours. The yield is 99.3%, and the water content is 2.09%.

Embodiment 2

[0024] The preparation of embodiment 2 cefuroxime sodium crystal form compound

[0025] Disperse 100g of cefuroxime sodium in 1000ml of 98% methanol, heat to 50°C, stir for 1.5h, filter while hot, and dry in vacuum at 40°C for 4h. The yield is 96.3%, and the water content is 2.07%.

Embodiment 3

[0026] Preparation of Example 3 Cefuroxime Sodium Crystal Form Compound

[0027] Disperse 100g of cefuroxime sodium in 800ml of 98% acetone, heat to 40°C, stir for 2h, filter while hot, and dry in vacuum at 40°C for 4h. The yield is 99.1%, and the water content is 2.07%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine, and in particular relates to a preparation method of cefuroxime sodium crystal form compound. The crystal form sample of cefuroxime sodium of the present invention can be obtained by the following method: disperse cefuroxime sodium in an aqueous organic solvent, stir at 45°C to 65°C for several hours, filter and dry to obtain cefuroxime Octyl sodium crystal compound. The cefuroxime sodium prepared by the invention has low hygroscopicity, good stability and good fluidity, and solves the problems of rapid color change and poor stability of the existing cefuroxime sodium.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method of cefuroxime sodium crystal form compound. [0002] technical background [0003] Cefuroxime sodium belongs to β-lactam antibiotics and belongs to the second-generation cephalosporin products. It not only has strong antibacterial activity against Gram-positive cocci, but also has good antibacterial activity against some Gram-negative bacteria. antibacterial activity. Cefuroxime sodium is not metabolized by the liver in the body, so it has no toxicity to the liver, so its medication is very safe. [0004] Cefuroxime Sodium was developed by Glaxo, and it was first launched in the UK in 1978, and then successively in Italy, the UK, France and China. At present, cefuroxime sodium still occupies a large share in the antibiotic market. [0005] The chemical structure of cefuroxime sodium is as follows: [0006] [0007] The thermal stability of cefuroxime sod...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/34C07D501/12
Inventor 谭胜连贾永兵唐康文青张旭途
Owner GUANGZHOU BAIYUSN TIANXIN PHARMA