Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Peptide for promoting osteoanagenesis or osteogenesis and use of same

A technology of bone regeneration and derivatives, applied in the direction of medical preparations containing active ingredients, peptides, bone diseases, etc., can solve the problems of undeveloped effective and powerful drug candidates, and achieve storage and stability advantages, chemical structure Simple, bone regeneration-promoting effect

Active Publication Date: 2019-06-07
(株)世援生命工学
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently no effective and potent drug candidates have been developed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Peptide for promoting osteoanagenesis or osteogenesis and use of same
  • Peptide for promoting osteoanagenesis or osteogenesis and use of same
  • Peptide for promoting osteoanagenesis or osteogenesis and use of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0194] Example 1. Preparation of peptides of the present invention

[0195] The peptides used in the examples were synthesized by the 9-fluorenylmethoxycarbonyl (Fmoc) method (Lugen Sci, Korea; Peptron, Korea). In order to confirm the reproducibility of the experimental results using peptides, the same group of peptides were independently synthesized 2 or 3 times by Lugen Sci and Peptron, respectively. Consistent results were obtained from peptides synthesized from different companies and between different batches.

Embodiment 2

[0196] Example 2. Effect of peptides of the invention on cell adhesion as a major mechanism of bone regeneration

[0197] Peptides having the sequence represented by SEQ ID NO: 17 were used to test the peptides of the present invention for promoting bone regeneration in a xenograft bone model and in the following examples unless otherwise stated.

[0198] As described below, each of the following four groups was transplanted onto the backs of immunodeficient mice using graft materials having the components shown in Table 2, and the newly formed hard tissues were analyzed at 3 and 6 weeks after transplantation. organize. The doses used are as follows: Geistlich Bio-Oss: 100 mg; hDPSC (human dental pulp stem cells): 5x10 6 Cells; peptide according to the invention: 10 μg; and BMP-2 (BD Science): 2 μg (Kevin et al., Adv Drug Deliv Rev. 2012; 64:1277-1291).

[0199] Table 2

[0200]

[0201] For animal experiments, 6-week-old immunocompromised mice (NIH-bg-nu / nu-xid, HarlanS...

Embodiment 3

[0207] Example 3. Promotion of bone regeneration in a calvarial defect model by the peptides of the invention.

[0208] Using a skull defect model, the bone regeneration ability of the peptides according to the present invention was analyzed as follows.

[0209] First, transplanted materials having components corresponding to the respective conditions in Table 3 were used as animal models on laboratory rats. Eight-week-old male rats were used to avoid errors caused by hormonal changes. The experimental animals were bred and managed according to the standards of the Experimental Animal Center of Seoul National University. After preparing the implants according to the conditions shown in Table 3, fractures of specific sizes were surgically induced in the skulls of rats and treated with the implants. At 3 and 5 weeks after transplantation, newly formed bone tissue was examined. Bone regeneration peptide and BMP-2 were diluted in saline, and the same volume of saline was used a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The present application discloses a peptide for promoting osteoanagenesis or osteogenesis, and a composition including same. The peptide or the composition including the same according to the presentapplication has osteoanagenesis and osteogenesis functions in heterogenous bones and allogenic bones and promotes osteogenesis in a generation process too. In addition, the peptide or the compositiondoes not exhibit heterotropic ossification. Accordingly, the composition including the peptide according to the present application can be applied to treatments of various diseases requiring osteoanagenesis and osteogenesis functions. Moreover, the peptide according to the present application can ensure safety by replacing BMP-2 or by being used with small quantities of BMP-2.

Description

technical field [0001] The present disclosure relates to techniques that can promote bone regeneration and bone formation. Background technique [0002] The population over 60 years old is expected to account for 21.8% of the total population by 2050, so aging, metabolic diseases and other bone diseases will continue to increase. [0003] Fractures in the elderly and osteoporotic patients are known to have a low rate of fusion of the injured site, and for osteoporotic patients over the age of 70, fractures are known to be associated with high mortality due to reduced quality of life . [0004] Therefore, medical technology that can effectively and quickly treat fractures has become an important social issue. When bone tissue is affected by infection, trauma, and disease, it becomes very slow to heal naturally. The rate further decreases with age. Therefore, rapid and accurate recovery and healing based on bone regeneration is more important than any disease in considerat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06C07K7/08A61K38/08A61K38/10A61P19/02A61P19/08
CPCA61K38/08A61K38/10C07K7/06C07K7/08A61P19/00A61K38/00A61P19/08
Inventor 尹源晙
Owner (株)世援生命工学
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com