Oxygen nitrogen heterocyclic heptane derivative containing exocyclic double bond and preparation method thereof

Abstract

The invention provides an oxygen nitrogen heterocyclic heptane derivative containing an exocyclic double bond and a preparation method thereof. The preparation method comprises the following steps that tetraacetylene compounds are mixed with methylbenzene toluene to perform heating reaction with 2,4,4-trimethyl-2-oxazoline, and after the reaction is finished, the mixture is naturally cooled to room temperature, and a product is purified and separated to obtain the oxygen nitrogen heterocyclic heptane derivative containing the exocyclic double bond. Compared with the prior art, the invention provides the novel preparation method of the oxygen nitrogen heterocyclic heptane derivative containing the exocyclic double bond. Compared with common heterocyclic derivatives, the oxygen nitrogen heterocyclic heptane derivative containing the exocyclic double bond has the existence of the exocyclic double bond and oxygen-nitrogen heteroatoms, and a rare seven-membered ring structure is obtained, and the structure is more complex and novel. The substance of the oxygen nitrogen heterocyclic heptane derivative containing the exocyclic double bond may further have a wide range of functions in thepharmaceutical industry, and the preparation method is simple, convenient and efficient, has short reaction time and high efficiency.

Description

technical field [0001] The invention belongs to the field of organic compounds, and in particular relates to an oxazepane derivative containing an exocyclic double bond and a preparation method thereof. Background technique [0002] Heterocyclic compounds are cyclic compounds that contain one or more heteroatoms. The number and variety of heterocyclic compounds are various, and they are an important part of organic compounds. Most of the compounds distributed in nature contain heterocyclic systems. Most heterocyclic compounds have certain physiological activity and pharmacological value, and have important applications in the fields of natural products, pharmaceutical molecules, and functional materials. [0003] The development of efficient methods for the synthesis of novel heterocyclic compounds has always been a research hotspot in synthetic organic chemistry. The traditional method of synthesizing heterocyclic compounds mainly uses the condensation reaction of carbony...

AI Technical Summary

Problems solved by technology

However, the traditional synthetic route has problems such as harsh reaction conditions and low substrate universality.

In recent years, the synthesis of heterocyclic compounds based on transition metal-catalyzed cyclization reactions has attracted widespread attention from chemists, but the price of transition metals is high and it is easy to cause metal residues.

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