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Compound multi-component injection

An injection, multi-component technology, applied in the field of medicine, can solve problems such as side effects

Inactive Publication Date: 2019-06-18
董贵雨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, like most traditional Chinese medicine injections, Xuebijing Injection inevitably has side effects [see Huang Yingnan, Literature Analysis of 40 Cases of Xuebijing Adverse Reactions, China Urban and Rural Enterprise Health, Issue 4, August 2012]

Method used

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  • Compound multi-component injection
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  • Compound multi-component injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0191] The preparation of embodiment 1 compound multi-component injection

[0192]

[0193] Preparation Process:

[0194] Step 1: Take 80% of the prescription amount of water for injection, add polysorbate 80, ascorbic acid in sequence, stir, and dissolve;

[0195] Step 2: Take the prescribed amount of Danshensu, Ligustrazine, Paeoniflorin, and Hydroxysafflower Yellow A in the solution obtained in Step 1, stir and dissolve;

[0196] Step 3: Take the prescribed amount of glycerin, add it to the solution obtained in step 2, stir and dissolve;

[0197] Step 4: Add water for injection to the full amount, and adjust the pH value of the solution obtained in step 3 to 5.5-6.0 with 0.1M hydrochloric acid or sodium hydroxide;

[0198] Step 5: Take the medicinal liquid obtained in step 4, add 0.1% activated carbon, let it stand for 30 minutes, absorb endotoxin, and pass through the 0.22um microporous membrane twice to remove the activated carbon;

[0199] Step 6: Take the medicina...

Embodiment 2

[0201] The preparation of embodiment 2 compound multi-component injection freeze-dried powder

[0202]

[0203] Preparation:

[0204] Step 1: Take 80% of the prescription amount of water for injection, add polysorbate 80, ascorbic acid in sequence, stir, and dissolve;

[0205] Step 2: Take the prescribed amount of Danshensu, Ligustrazine, Paeoniflorin, and Hydroxysafflower Yellow A in the solution obtained in Step 1, stir and dissolve;

[0206] Step 3: Take the prescribed amount of freeze-dried support agent (mannitol, dextran 40 or dextran 60), add it to the solution obtained in step 2, stir and dissolve;

[0207] Step 4: Add water for injection to the full amount, and adjust the pH value of the solution obtained in step 3 to 5.5-6.0 with 0.1M hydrochloric acid or sodium hydroxide;

[0208] Step 5: Take the medicinal liquid obtained in step 4, add 0.1% activated carbon, let it stand for 30 minutes, absorb endotoxin, and pass through the 0.22um microporous membrane twice ...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a compound multi-component injection and a preparation process and application thereof. The compound multi-component injection is used for treating sepsis, cannot cause adverse reactions such as allergy and is good in stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a compound multi-component injection and its preparation process and application. Background technique [0002] Sepsis is a fatal organ dysfunction caused by an imbalanced host response to infection, and its in-hospital mortality rate is as high as 10%, which has posed a huge threat to human health and has become the focus of medical attention [see JAMA.2016Feb 23 ;315(8):801-10]. After retrospective analysis of big data, combined with microarray technology and leukocyte gene expression analysis, people gradually realized that sepsis is not only a process of systemic inflammatory response or immune dysregulation, but also a process of continuous inflammation, immunosuppression, and catabolism. Combined complex chronic critical illness. [See J Trauma AcuteCare Surg.2012June;72(6):1491-501, BMJ.2016May 23;353:i1585 and Medicine (Baltimore).2015Dec;94(50):e2044.]. ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7048A61K31/4965A61K31/192A61K31/351A61P31/00
Inventor 不公告发明人
Owner 董贵雨
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