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Composition comprising reactive phenolic compound and vinylpyrrolidone copolymer which is sparingly soluble in water

A technology of vinylpyrrolidone and polyphenolic compounds, applied in the field of keratin substances, can solve the problems of poor stability and bioavailability of active compounds and the like

Active Publication Date: 2022-04-01
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Compositions comprising active compounds that are sparingly soluble in water, such as cosmetic or dermatological products, have the problem of poor stability and bioavailability of the active compounds if the composition is aqueous

Method used

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  • Composition comprising reactive phenolic compound and vinylpyrrolidone copolymer which is sparingly soluble in water
  • Composition comprising reactive phenolic compound and vinylpyrrolidone copolymer which is sparingly soluble in water
  • Composition comprising reactive phenolic compound and vinylpyrrolidone copolymer which is sparingly soluble in water

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-7 and comparative example 1-12

[0175] [preparation]

[0176] Each composition according to Examples 1-7 and Comparative Examples 1-12 was prepared by mixing the ingredients shown in Tables 1 and 2 at room temperature (20-25° C.). The values ​​for the amounts of ingredients are all based on "% by weight" based on active raw materials. Note that citric acid or potassium hydroxide is added to adjust the pH of the composition to around 7.0.

[0177]

[0178]

[0179] Tables 1 and 2 indicate the following information about the compositions according to Examples 1-7 and Comparative Examples 1-12.

[0180] (1) The pH of the composition is in the "pH" row

[0181] (2) Whether the polymer in the composition has vinylpyrrolidone groups (as "yes" or "no") in the row "Presence of VP groups"

[0182] (3) Whether the polymer in the composition is nonionic or cationic (as a "yes" or "no") in the row "nonionic or cationic"

[0183] [Evaluation]

[0184] (stability)

[0185] The stability of each composition accor...

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PUM

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Abstract

The present invention relates to compositions comprising: (a) at least one polyphenolic compound which is sparingly soluble in water; (b) at least one nonionic or cationic vinylpyrrolidone copolymer; (c) water; and (d ) at least one basic amino acid. The present invention can provide compositions comprising a slightly water-soluble polyphenolic compound and water, which have increased solubility of the slightly water-soluble polyphenolic compound, while providing the composition with good texture, such as less viscosity and freshness .

Description

technical field [0001] The present invention relates to compositions, especially cosmetic compositions, preferably for keratinous substances, such as the skin, comprising polyphenolic compounds which are sparingly soluble in water. Background technique [0002] Compositions comprising active compounds which are sparingly soluble in water, such as cosmetic or dermatological products, have the problem of poor stability and bioavailability of the active compounds if the composition is aqueous. So far, in order to solve these problems, some prior art describes methods for increasing the aqueous solubility of sparingly water-soluble active compounds. [0003] For example, WO2013 / 106,433 discloses a composition comprising a cellulose ester and a sparingly water-soluble drug, wherein the cellulose ester increases the solubility of the drug compared to the drug alone. [0004] In addition, WO2013 / 158992 discloses a composition for increasing the solubility of a solute compound, com...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/81A61K8/34A61Q19/02
CPCA61K8/347A61K8/8182A61Q19/02A61K2800/594A61K8/44A61K8/498A61K8/602
Inventor 饭间雄介胡璠神保和子
Owner LOREAL SA