Method for continuous co-production of glycine and hydantoin

A technology of glycine and hydantoin, applied in organic chemistry and other directions, can solve the problems of low-value inorganic salts, high production costs and high prices

Inactive Publication Date: 2019-07-05
HUAYANG NEW MATERIAL TECH GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the raw material of this method, hydrocyanic acid, is highly toxic and volatile, and cannot be transported over long distances, thus restricting its popularization and application.
[0007] (5) Aminoacetonitrile method, that is, react hydroxyacetonitrile with ammonia water to obtain aminoacetonitrile, then add inorganic base to carry out alkaline hydrolysis, then add inorganic acid to neutralize to obtain glycine reaction solution, and then obtain glycine through the steps of concentration, decolorization, crystallization and classification, The mother liquor is recycled; however, this method has the disadvantages of many side reactions, difficult product separation, and long desalination process
Glycine, the main raw material of the glycine method, is easy to purchase, but the price is relatively high, and a large amount of low-value inorganic salts will be produced during the production process, resulting in high production costs; the hydroxyacetonitrile method can only achieve small-scale production in a single tank at present

Method used

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  • Method for continuous co-production of glycine and hydantoin
  • Method for continuous co-production of glycine and hydantoin
  • Method for continuous co-production of glycine and hydantoin

Examples

Experimental program
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Effect test

Embodiment 1

[0048] Hydroxyacetonitrile, ammonium bicarbonate, and water are mixed according to the ratio of 1:2:50, and transported by the metering pump to the tubular reactor at 143L / min for synthetic hydantoin reaction. The reaction temperature is 100°C, the pressure is 2.0MPa, The residence time is 20min, and then the feed liquid enters the flash tower to remove all CO 2 , some NH 3 and a small amount of water, 1 / 4 of the obtained synthetic hydantoin reaction liquid enters the evaporator, and the remaining 3 / 4 enters the tank reactor. The reaction liquid that enters the evaporator is evaporated and concentrated to 1 / 3 of the original volume, then enters the acidification reactor, adds 98wt% concentrated sulfuric acid equivalent to 15wt% of the concentrated solution, and reacts for 2 hours at 90°C for acidification (cyclization), and then enters the decolorization reactor 1, add 2wt% activated carbon, decolorize at 90°C for 0.5 hour, then filter, crystallize, centrifuge, and dry to obt...

Embodiment 2

[0050] Hydroxyacetonitrile, ammonium bicarbonate, and water are mixed according to the ratio of 1:3:55, and transported by the metering pump to the tubular reactor at 151L / min for synthetic hydantoin reaction. The reaction temperature is 110°C, the pressure is 2.5MPa, The residence time is 18min, and then the feed liquid enters the flash tower to remove all CO 2 , some NH 3 and a small amount of water, 1 / 4 of the obtained synthetic hydantoin reaction liquid enters the evaporator, and the remaining 3 / 4 enters the tank reactor. The reaction liquid that enters the evaporator is evaporated and concentrated to 1 / 3 of the original volume, then enters the acidification reaction tank, adds 98 wt% concentrated sulfuric acid equivalent to 15 wt% of the concentrated solution, and reacts for 2.5 hours at 90°C for acidification (cyclization), and then enters the decolorization tank 1, add 3wt% activated carbon, decolorize at 90 DEG C for 0.6 hours, then filter, crystallize, centrifuge, an...

Embodiment 3

[0052] Hydroxyacetonitrile, ammonium bicarbonate, and water are mixed according to the ratio of 1:3.5:60, and transported by the metering pump to the tubular reactor at 135L / min for synthetic hydantoin reaction. The reaction temperature is 90°C, the pressure is 2.0MPa, The residence time is 23min, and then the feed liquid enters the flash tower to remove all CO 2 , some NH 3 and a small amount of water, 1 / 2 of the resulting synthetic hydantoin reaction liquid enters the evaporator, and the remaining 1 / 2 enters the tank reactor. The reaction liquid that enters the evaporator is evaporated and concentrated to 1 / 4 of the original volume, then enters the acidification reactor, adds 98wt% concentrated sulfuric acid equivalent to 17wt% of the concentrated solution, and reacts for 3 hours at 90°C for acidification (cyclization), and then enters the decolorization reactor 1, add 2.5wt% activated carbon, decolorize at 90°C for 0.6 hours, then filter, crystallize, centrifuge, and dry t...

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Abstract

A method for continuous co-production of glycine and hydantoin is provided. The method includes subjecting an amino source, a carbon source, water and hydroxyacetonitrile to a hydantoin synthesizing reaction in a shell-and-tube reactor to obtain a first reaction product; feeding the first reaction product into a flash column for treatment to obtain a first treatment product; dividing the first treatment product into a first portion and a second portion; subjecting the first portion to first concentration treatment in an evaporator to obtain a first concentrate; reacting the first concentrate with concentrated sulfuric acid to obtain a second reaction product including hydantoin; subjecting the second portion to hydantoin decomposition in a tank series reactor to obtain a third reaction product including glycine. Compared with the prior art, the method realizes the continuous co-production of the glycine and the hydantoin.

Description

technical field [0001] The invention relates to the field of fine chemical industry, in particular to a method for continuous production of glycine and co-production of hydantoin. Background technique [0002] Glycine, also known as aminoacetic acid, English Glycine, chemical formula C 2 h 5 NO 2 , with a molecular weight of 75.07, is the amino acid with the simplest structure. As an important fine chemical intermediate, it is widely used in the fields of pesticide, medicine, food, feed, daily chemical and organic synthesis. my country is the largest producer and consumer of glycine in the world, and the market size of glycine exceeds 350,000 tons. However, several glycine production methods in the prior art still have some disadvantages. E.g: [0003] (1) Hydrolysis method: Glycine is obtained by hydrolyzing, separating, refining, filtering, and drying natural proteins such as gelatin or silk as raw materials. This method consumes a lot of protein raw material, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/72
CPCC07D233/72
Inventor 张伟龚文照李鑫韩萌杨任俊毋楠赫瑞元赵广胡慧敏李凯孟迎袁秋华李伟斌
Owner HUAYANG NEW MATERIAL TECH GRP CO LTD
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