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Gel-skeleton-type ivermectin sustained-release tablet with regulating layer

A gel skeleton, ivermectin technology, which is applied in the directions of non-active ingredients medical preparations, pill delivery, organic active ingredients, etc. The preparation method is simple and easy to operate, with good sustained-release effect and less irritating effect.

Pending Publication Date: 2019-07-09
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disintegration process of the patented product will bring about a certain burst release, the preparation of protein microspheres is relatively complicated, and the dosage control is not easy to be precise

Method used

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  • Gel-skeleton-type ivermectin sustained-release tablet with regulating layer
  • Gel-skeleton-type ivermectin sustained-release tablet with regulating layer
  • Gel-skeleton-type ivermectin sustained-release tablet with regulating layer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Preparation of drug-containing gel skeleton bitterness masking layer: weigh ivermectin, hydrophilic gel skeleton material, and bitterness masking agent auxiliary materials according to the following requirements, pass through a 30-mesh sieve repeatedly, and then mix with the filling layer and porogen , Polyethylene glycol is fully shaken and mixed, adding an appropriate amount of PVPK30 aqueous solution to make a soft material, passing through a 100-mesh sieve repeatedly, drying at a constant temperature of 50-70°C for 2-4 hours, sealing and cooling, adding lubricant, fully mixing, passing 20 Mesh sieve, sealed for use.

[0040]

[0041] (2) Preparation of the control layer: Weigh the material of the control layer according to the following requirements: pass the auxiliary materials of the control layer through an 80-mesh sieve and mix well, add an appropriate amount of wetting agent to make a soft material; then pass through a 100-mesh sieve twice to make it even...

Embodiment 2

[0046] (1) Preparation of drug-containing gel skeleton bitterness masking layer: weigh ivermectin, hydrophilic gel skeleton material, and bitterness masking agent auxiliary materials according to the following requirements, pass through a 30-mesh sieve repeatedly, and then mix with the filling layer and porogen , Polyethylene glycol is fully shaken and mixed, adding an appropriate amount of PVPK30 aqueous solution to make a soft material, passing through a 100-mesh sieve repeatedly, drying at a constant temperature of 50-70°C for 2-4 hours, sealing and cooling, adding lubricant, fully mixing, passing 20 Mesh sieve, sealed for use.

[0047]

[0048] (2) Preparation of the control layer: preparation of the control layer: take the material of the control layer according to the following requirements: pass the auxiliary materials of the control layer through an 80-mesh sieve and fully mix them evenly, add an appropriate amount of wetting agent to make a soft material; then pass ...

Embodiment 3

[0053] (1) Preparation of drug-containing gel skeleton bitterness masking layer: weigh ivermectin, hydrophilic gel skeleton material, and bitterness masking agent auxiliary materials according to the following requirements, pass through a 30-mesh sieve repeatedly, and then mix with the filling layer and porogen , Polyethylene glycol is fully shaken and mixed, adding an appropriate amount of PVPK30 aqueous solution to make a soft material, passing through a 100-mesh sieve repeatedly, drying at a constant temperature of 50-70°C for 2-4 hours, sealing and cooling, adding lubricant, fully mixing, passing 20 Mesh sieve, sealed for use.

[0054]

[0055] (2) Preparation of the control layer: Weigh the material of the control layer according to the following requirements: pass the auxiliary materials of the control layer through an 80-mesh sieve, mix them well, and add an appropriate amount of wetting agent to make a soft material. Then pass through a 100-mesh sieve twice to make ...

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Abstract

The invention provides a novel gel-skeleton-type ivermectin sustained-release parasite expelling tablet and a preparation method thereof. The novel gel-skeleton-type ivermectin sustained-release parasite expelling tablet mainly used for treating parasitic disease of livestock and poultry comprises a regulating layer, a hydrophilic gel skeleton layer, drugs, a bitter taste shielding layer and otherfillers, wherein the regulating layer, ivermectin, the hydrophilic gel skeleton layer and the bitter taste shielding layer account for 18-40%, 0.4-1.25%, 40-60% and 1-5% respectively. The new dosageform of hydrophilic gel skeleton type ivermectin with the regulating layer is developed, the sustained release effect is good, and the toxicity of sudden release on the body is inhibited; the tablet can be continuously taken for more than 20 days to maintain the stable blood concentration for a long time; most of the bitter taste is shielded, and the irritation to the mouth and stomach is small; the problems of the ivermectin, such as bitterness, sudden release, and irritation to and poisoning of the body, are solved.

Description

technical field [0001] The invention belongs to the field of veterinary pharmaceutical preparations, and in particular relates to a gel-skeleton sustained-release tablet with a control layer and a preparation method thereof. Background technique [0002] Compared with developed countries, the prevention and control technology of livestock and poultry parasitic diseases in my country is still lagging behind, especially in remote areas with poor economic conditions, the "autumn fat, winter thin, spring death" of livestock still exists, and some endemic zoonoses Suffering from parasitic diseases is still serious, and even endangers or threatens the health and even life safety of local people. Therefore, strengthening the prevention and control of livestock and poultry parasitic diseases is of great significance to improving the productivity of livestock and poultry, promoting the sustainable and healthy development of the livestock industry, and comprehensively improving the hyg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/22A61K47/38A61P33/10A61P33/14
CPCA61K31/7048A61K9/2054
Inventor 井丁丁聂丽娜李晓慧
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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