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A kind of preparation method of degradable aliphatic copolyester

A technology for degrading fat and copolyester, which is applied in the field of preparation of degradable aliphatic copolyester, can solve the problem that the synthesis and performance research of aliphatic copolyester is very small, it is difficult to form multi-block copolymers, and it is difficult to form high molecular weight polymer. Ester and other problems, to achieve the effect of large application value, low cost, and no need for post-treatment

Active Publication Date: 2021-04-13
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the two- and three-block copolymers obtained by ring-opening polymerization are generally difficult to form multi-block copolymers; while aliphatic polydiacid glycol esters are synthesized by condensation polymerization of aliphatic diacids and diols. There are many side reactions in the process, and it is not easy to obtain high molecular weight polyester
[0004] At present, there is still no effective method to introduce a higher content of functional groups into degradable copolyesters, and there are very few studies on the synthesis and properties of degradable aliphatic copolyesters

Method used

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  • A kind of preparation method of degradable aliphatic copolyester
  • A kind of preparation method of degradable aliphatic copolyester
  • A kind of preparation method of degradable aliphatic copolyester

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Example 1 Degradable aliphatic copolyester (PEBDB) produced by in-situ ring-opening-condensation cascade polymerization by mixing decanediol and musk T

[0041] Add decanediol (0.05 g) and musk T (5.00 g) into a 100 ml three-necked flask, pass nitrogen gas to remove oxygen, place the three-necked flask in a salt bath and heat to 200 degrees Celsius, and mechanically stir, then add Slowly add 10.1 microliters of n-butyl titanate to the sample vessel, and perform in-situ ring-opening-condensation cascade polymerization reaction under nitrogen atmosphere to generate corresponding polymers. Samples were taken every 30 minutes during the reaction, and the reaction was stopped after 120 minutes.

[0042] The size exclusion chromatogram and the molecular weight of the copolyester change with time are shown in figure 2 , image 3 , demonstrating the successful synthesis of the target product, whose molecular weight can be controlled by controlling the polymerization time. I...

Embodiment 2

[0043] Example 2 Degradable aliphatic copolyester (PEBDB) produced by in-situ ring-opening-condensation cascade polymerization by mixing decanediol and musk T

[0044] Add decanediol (0.50 g) and musk T (5.00 g) into a 100 ml three-necked flask, pass nitrogen gas to remove oxygen, place the three-necked flask in a salt bath and heat to 240 degrees Celsius, and mechanically stir, followed by micro-injection 11.0 microliters of n-butyl titanate was slowly added to the sample vessel, and in-situ ring-opening-condensation cascade polymerization was carried out under a nitrogen atmosphere to generate corresponding polymers. Samples were taken every 30 minutes during the reaction, and the reaction was stopped after 120 minutes.

[0045] Molecular weight of copolyester with time Figure 4 , demonstrating the successful synthesis of the target product, whose molecular weight can be controlled by controlling the polymerization time. It can be calculated that the mass content of funct...

Embodiment 3

[0046] Example 3 In situ ring-opening-condensation cascade polymerization by mixing decanediol and musk T to generate degradable aliphatic copolyester (PEBDB)

[0047] Add decanediol (3.00 g) and musk T (10.0 g) into a 100 ml one-necked flask, and slowly add 26.0 μl of n-butyl titanate through a microsampler. The single-necked flask was placed in a salt bath and heated to 200 degrees Celsius, and mechanically stirred, reacted for 10 minutes under nitrogen atmosphere, and then vacuumed and polymerized for 30 minutes to finally generate the corresponding polymer.

[0048] For size exclusion chromatograms see Figure 5 , the measured molecular weight was 20.3 kg per mole, proving the successful synthesis of the target product. It can be calculated that the mass content of functional groups in the copolyester is about 23%.

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Abstract

The invention discloses a method for preparing a degradable aliphatic copolyester. The aliphatic macrolide is used as a monomer, and diol is used as an initiator. In the presence of a catalyst, an in-situ ring-opening-condensation cascade polymerization reaction is carried out. The degradable aliphatic copolyester is prepared; the diol is a small molecular diol or a macromolecular diol. The copolyester disclosed by the invention has a higher molecular weight and a higher content of functional groups, and the mass content of functional groups in the copolyester can reach 75%; the copolyester has degradability, and The degradation rate is controlled by conditions such as temperature and enzymes.

Description

technical field [0001] The invention belongs to the field of polymer material preparation, and particularly relates to the preparation of a degradable aliphatic copolyester. Background technique [0002] At present, polymer materials based on olefin synthesis are stable in nature and difficult to degrade in nature, causing serious "white pollution" problems. As people pay more and more attention to environmental issues and their own health, environmentally friendly materials have developed rapidly in recent years. Among these materials, aliphatic polyesters have many unique advantages, such as being prepared from renewable bio-based derivatives, recyclable, biocompatible, and biodegradable. In addition, amphiphilic aliphatic polyester-based block copolymers can self-assemble in water to form micelles, and can entrap poorly water-soluble drugs in micelles, and have good biocompatibility, Biodegradable and other characteristics, so it has broad application prospects in the f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/16C08G63/672C08G63/682
CPCC08G63/16C08G63/672C08G63/6826
Inventor 屠迎锋万雪婷徐思源
Owner SUZHOU UNIV
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