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Crystallization method of L-lysine hydrochloride

A lysine hydrochloride crystallization technology, applied in the field of crystallization of L-lysine hydrochloride, can solve the problems of low crystallization yield and slow crystallization rate of L-lysine hydrochloride, and achieve The effect of increasing crystallization yield and increasing crystallization rate

Active Publication Date: 2019-08-06
上海泰坦科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] For the deficiencies in the prior art, the object of the present invention is to provide a kind of crystallization method of L-lysine hydrochloride, to solve the crystallization yield of L-lysine hydrochloride in the existing method is not high, the crystallization rate slower problem

Method used

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Examples

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Effect test

Embodiment 1

[0037] This embodiment provides a crystallization method of L-lysine hydrochloride

[0038] Concentrate the aqueous solution of L-lysine hydrochloride with a concentration of 65% at 80°C for the first time, concentrate the concentration to 80%, and then add n-butanol, n-butanol and L-lysine at a temperature of 73°C The volume ratio of the hydrochloride aqueous solution is 1:7, and at the same time, the temperature is lowered to 15°C under the bubbling of saturated steam for 25 minutes, and after filtration, the air is dried with air at a temperature of 70°C to obtain L-lysine hydrochloride.

Embodiment 2

[0040] This embodiment provides a crystallization method of L-lysine hydrochloride

[0041] Concentrate the aqueous solution of L-lysine hydrochloride with a concentration of 70% at 85°C for the first time, concentrate the concentration to 85%, and then add absolute ethanol at a temperature of 70°C, absolute ethanol and L-lysine The volume ratio of the hydrochloride aqueous solution is 1:8, and at the same time, the temperature is lowered to 10°C under the bubbling of saturated steam for 30 minutes, and after filtration, the air is dried with air at a temperature of 75°C to obtain L-lysine hydrochloride.

Embodiment 3

[0043] This embodiment provides a crystallization method of L-lysine hydrochloride

[0044] Concentrate the aqueous solution of L-lysine hydrochloride with a concentration of 60% at 78°C for the first time, concentrate the concentration to 75%, and then add anhydrous methanol at a temperature of 75°C, anhydrous methanol and L-lysine The volume ratio of the hydrochloride aqueous solution is 1:4, and at the same time, the temperature is lowered to 20°C under the bubbling of saturated steam for 20 minutes, and after filtration, air-drying is performed with air at a temperature of 65°C to obtain L-lysine hydrochloride.

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Abstract

The present invention provides a crystallization method of L-lysine hydrochloride. The crystallization method comprises the following steps: primarily concentrating an aqueous solution of L-lysine hydrochloride, then adding an organic solvent, and cooling the obtained solution while pumping in saturated steam to obtain the L-lysine hydrochloride. Compared with direct recrystallization or concentrating crystallization methods, the method in the invention, combining three processes of concentration, organic solvent and steam pump-in, can increase the crystallization rate and the crystallizationyield of the L-lysine hydrochloride on the premise of ensuring the crystallization purity, makes the highest crystallization yield reach up to 80% or above, allows the precipitated crystal form to besingle, and has great significance and values in the production and market application of L-lysine.

Description

technical field [0001] The invention belongs to the field of biological separation and relates to a crystallization method of L-lysine hydrochloride. Background technique [0002] Lysine is one of the most important amino acids and one of the essential amino acids for the human body. It can promote human development, enhance immune function, and improve the function of central nervous tissue. It can improve intelligence, promote growth, and enhance physical fitness. Increase appetite and improve malnutrition. Improve insomnia and improve memory. Help produce antibodies, hormones and enzymes, improve immunity, increase hemoglobin. Help the absorption of calcium, treat and prevent osteoporosis, reduce the level of triglycerides in the blood, and prevent the occurrence of cardiovascular and cerebrovascular diseases. . Lysine is a basic essential amino acid. Since the content of lysine in grain food is very low, and it is easily destroyed and lacked during processing, it is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/26C07C227/42
CPCC07C227/42C07C229/26
Inventor 谢应波张庆张华徐肖冰罗桂云张维燕
Owner 上海泰坦科技股份有限公司
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