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Modified organic acid and preparation method thereof

An organic acid and modification technology, applied in the field of medicine, can solve the problems of skin corrosion, organic solvents are harmful to the human body, and organic acids are easy to precipitate, and achieve the effect of enhancing stability and solubility.

Inactive Publication Date: 2019-08-16
NMS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the organic acids used in cosmetics for cleansing the face on the market are poor in water solubility, and an additional organic solvent must be added to dissolve the organic acid, which leads to the easy precipitation of the organic acid after the product is left for a long time, and some organic solvents are harmful to the human body
And the organic acid directly acts on the human skin, which is easy to corrode the skin

Method used

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  • Modified organic acid and preparation method thereof
  • Modified organic acid and preparation method thereof
  • Modified organic acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Dissolve 0.2g and 2g of PEG-400 and α-cyclodextrin into 20 mL of deionized water to obtain a mixed solution;

[0033] 2) Put the mixed solution at room temperature and stir for 2 days, then stand for one day, filter, and dry at 100°C for 3 hours to obtain a solid;

[0034] 3) Thoroughly mix and grind the solid and salicylic acid with masses of 1g and 0.05g to obtain a mixture;

[0035] 4) Put the mixture in an open pressure bottle without applying extra pressure. Heat to 150°C and keep for 3h to obtain modified salicylic acid with a purity of 99% and a melting point of 173°C.

[0036] In the above-mentioned modified organic acid, the organic acid is bonded to the central cavity of the cyclodextrin by hydrogen bonding. The structural formula of the modified organic acid is as follows:

[0037]

[0038] Wherein: R is salicylic acid; n is 1; R1 is hydrogen.

Embodiment 2

[0040] 1) Dissolve 1g of both PEG-800 and β-cyclodextrin into 20mL of deionized water to obtain a mixed solution;

[0041] 2) Put the mixed solution at room temperature and stir for 2 days, then stand for one day, filter, and dry at 100°C for 3 hours to obtain a solid;

[0042] 3) Thoroughly mix and grind the solid and salicylic acid with masses of 1g and 0.2g to obtain a mixture;

[0043] 4) Place the mixture in a sealed pressure bottle. It is heated to 150°C and the absolute pressure is maintained at 1.5 bar. Keep it for 3h to obtain modified salicylic acid with a purity of 99% and a melting point of 171.5°C.

[0044] In the above-mentioned modified organic acid, the organic acid is bonded to the central cavity of the cyclodextrin by hydrogen bonding. The structural formula of the modified organic acid is as follows:

[0045]

[0046] Wherein: R is salicylic acid; n can be 2; R1 is hydrogen.

Embodiment 3

[0048] 1) Dissolve 2g and 1g of PEG-1000 and γ-cyclodextrin into 20 mL of deionized water respectively to obtain a mixed solution;

[0049] 2) Put the mixed solution at room temperature and stir for 2 days, then stand for one day, filter, and dry at 100°C for 3 hours to obtain a solid;

[0050] 3) Thoroughly mix and grind the solid and azelaic acid with a mass of 1 g and 0.4 g to obtain a mixture;

[0051] 4) Place the mixture in a sealed pressure bottle. Heat to 150°C and keep the absolute pressure at 1.6 bar. Keep it for 3h to obtain modified azelaic acid with a purity of 99% and a melting point of 165°C.

[0052] In the above-mentioned modified organic acid, the organic acid is bonded to the central cavity of the cyclodextrin by hydrogen bonding. The structural formula of the modified organic acid is as follows:

[0053]

[0054] Wherein: R is azelaic acid; n is 3; R1 is hydrogen.

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Abstract

The invention provides a modified organic acid and a preparation method thereof, and belongs to the field of medicine. The method comprises the steps: firstly, dissolving PEG and cyclodextrin into deionized water to obtain a mixed solution; secondly, placing the mixed solution at room temperature, stirring, standing, filtering and drying to obtain a solid; then, fully mixing and grinding the solidand organic acid, to obtain a mixture; and finally, placing the mixture in a sealed pressure-resistant bottle, and carrying out reaction to obtain the modified organic acid. The modified organic acidhas the advantages of good water solubility, high stability, and no additional addition of organic solvents.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a modified organic acid and a preparation method thereof. Background technique [0002] The organic acids used in the currently marketed cosmetics for cleansing the face are poor in water solubility, and an additional organic solvent must be added to dissolve the organic acid. This causes the organic acid to be easily precipitated after the product is stored for a long time, and some organic solvents are harmful to the human body. In addition, organic acids directly act on human skin and are prone to corrosion. Summary of the invention [0003] The present invention provides a modified organic acid and a preparation method thereof in view of the above-mentioned technical problems. [0004] The purpose of the present invention can be achieved through the following technical solutions: [0005] A method for preparing modified organic acid, the method includes the following step...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/86A61K8/362A61K8/365A61K8/368A61Q19/10
CPCA61K8/362A61K8/365A61K8/368A61K8/738A61K8/86A61K2800/56A61K2800/72A61Q19/10
Inventor 蔡友良黄龙强浩
Owner NMS TECH
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