Injectable hydrogel and preparation method thereof

A technology for injecting water and gel, applied in pharmaceutical formulations, surgery, drug delivery, etc., can solve problems such as poor mechanical properties and low cross-linking strength of hydrogels, and achieve good fluidity, ideal cross-linking strength, and preparation process. Safety and environmental protection effect

Active Publication Date: 2019-08-16
BEIJING UNIV OF CHEM TECH
View PDF3 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of hydrogel has low cross-linking strength and poor mechanical properties, which are greatly restricted in application.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Injectable hydrogel and preparation method thereof
  • Injectable hydrogel and preparation method thereof
  • Injectable hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0050] As mentioned earlier, there are always some problems in one way or another in existing multi-component hydrogels used as injectable hydrogels, and some need to use a large amount of toxic organic solvents when preparing their cross-linked substrates. The environment is very harmful, and its natural antibacterial and antiseptic properties are poor, so it cannot be used as an injectable hydrogel; some have low cross-linking strength and poor mechanical properties, which are greatly restricted in application. In view of this, the present inventors conducted extensive research on injectable hydrogels.

[0051] The inventors have found that the injectable hydrogel is prepared by using modified polysaccharides such as polylysine and carboxymethyl chitosan or alginylated sodium alginate as cross-linked substrates, less use of organic chemical reagents, The preparation process is safe and environment-friendly; the prepared injectable hydrogel is non-toxic and has ideal cross-li...

Embodiment 1

[0093] Add 8.00 g of polylysine to a 100 mL beaker, and then add 92 mL of deionized water to adjust the pH value to 7 to obtain a polylysine solution. Add 8.00g carboxymethyl chitosan in another 100mL beaker, add deionized water 92mL, obtain carboxymethyl chitosan solution. After the two component solutions are completely dissolved, add 0.7g EDC (carbodiimide) to the prepared carboxymethyl chitosan solution, and add 0.7g NHS (N-hydroxysuccinimide) to the prepared polylysine solution. amine), were stirred for 2h. It was sterilized at 121° C. for 30 minutes. After the sterilization, the two activated dispersions were mixed in equal volumes, and no hydrogel was formed.

Embodiment 2

[0095] Add 4.00 g of polylysine to a 100 mL beaker, and then add 96 mL of deionized water to adjust the pH to 9 to obtain a polylysine solution. Add 8.00g carboxymethyl chitosan in another 100mL beaker, add deionized water 92mL, obtain carboxymethyl chitosan solution. After the two component solutions are completely dissolved, add 0.7g EDC (carbodiimide) to the prepared carboxymethyl chitosan solution, and add 0.7g NHS (N-hydroxysuccinimide) to the prepared polylysine solution. amine), were stirred for 2h. It was sterilized at 121° C. for 30 minutes. After the sterilization, the two activated dispersions were mixed in equal volumes, and no hydrogel was formed.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to injectable hydrogel. The injectable hydrogel contains a chained or crosslinked polylysine unit and a chained or crosslinked modified polysaccharide unit, is non-toxic, has ideal crosslinking strength and mechanical properties as well as better fluidity and natural bacteriostatic and antiseptic properties, and can be widely applied in the aspects of medical hemostatic materials, medical dressings and treatment of xerophthalmia with punctual plugs; the invention also relates to a preparation method of the injectable hydrogel. According to the method, polylysine and modified polysaccharides are used as crosslinking substrates, and organic chemical reagents are seldom used, so that the preparation process is safe and environmentally-friendly.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and relates to an injectable hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a polymer material with a three-dimensional network structure, which has good water absorption and will neither break nor dissolve in water. The use of hydrogels in biomedical applications can be traced back to 1960. O.Wichterle and D.Lim prepared cross-linked poly(hydroxyethyl)methacrylate (pHEMA) hydrogels, which opened the field of hydrogels. new chapter. Because it contains a lot of water, has a porous structure and is very soft, it can simulate normal tissues very closely. The surface of the hydrogel is not easy to adhere to cells and proteins, so it shows good biocompatibility when in contact with human tissues. sex. After absorbing water, the hydrogel becomes soft and similar to normal tissue. Its three-dimensional network structure makes it have good mechanical...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/06A61L31/04C08J3/075C08L77/04C08L5/08C08L5/04
CPCA61L31/042A61L31/06A61L31/14A61L31/145A61L2400/06C08J3/075C08J2305/04C08J2305/08C08J2377/04C08J2477/04C08L77/04C08L5/08C08L5/04
Inventor 曹辉王宇灿谭天伟王馨莹
Owner BEIJING UNIV OF CHEM TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap