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Guanidyl macromolecule antibacterial nano microspheres and preparation method thereof

A nano-microsphere and macromolecule technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problems that the antibacterial masterbatch is not suitable for extrusion, the wall is adhered to the screw, the material performance is degraded, etc., and the preparation process is safe and environmentally friendly. Good bactericidal effect, less harm to human body and environment

Active Publication Date: 2016-05-04
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the good water solubility and strong hygroscopicity of polyguanidine salt, its application in plastics, fibers, rubber and coatings is limited
The application of polyguanidine in plastics has received extensive attention in recent years, but during the melting process of polyguanidine salt, it is easy to appear wall-mounted adhesion to screws and other phenomena (patent CN201010519982), resulting in antibacterial masterbatches that are not suitable for extrusion, and due to its water solubility The reason is that it is easy to slowly precipitate from the material matrix, resulting in a decrease in material performance

Method used

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  • Guanidyl macromolecule antibacterial nano microspheres and preparation method thereof
  • Guanidyl macromolecule antibacterial nano microspheres and preparation method thereof
  • Guanidyl macromolecule antibacterial nano microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] 1. prepare PSGMA polymer nanoparticle, comprise the steps:

[0053] Add 4.0 g of styrene to 130 mL of deionized water, stir, blow nitrogen to exhaust oxygen, heat to 75°C, and then add 10 mL of aqueous solution containing 0.1 g of potassium persulfate. After two hours of reaction, GMA3.0g was added, and the reaction was continued for 21h to stop the reaction. Aqueous sodium bicarbonate solution was added dropwise to adjust the pH to neutral. After centrifugation, washing, and drying in an oven at 50° C., a white powdery solid is obtained, which is PSGMA polymer nanoparticles.

[0054] 2. Characterization of PSGMA polymer nanoparticles

[0055] 1) The average particle diameter of the nanospheres in the PSGMA emulsion measured by dynamic light scattering method is 113.2nm.

[0056] 2) The prepared PSGMA polymer nanoparticles were characterized by Fourier transform infrared spectroscopy, the results are as follows: due to the characteristic peak of the epoxy bond at 125...

Embodiment 2

[0058] The preparation of PEMAGMA polymer nanoparticles comprises the following steps:

[0059] Add 4.0 g of ethyl methacrylate into 130 mL of deionized water, stir, blow nitrogen to exhaust oxygen, heat to 80°C, and add 10 mL of aqueous solution containing 0.1 g of potassium persulfate. After two hours of reaction, 3.0 g of GMA was added, and the reaction was continued for 18 hours to stop the reaction. Aqueous sodium bicarbonate solution was added dropwise to adjust the pH to neutral. After centrifugation, washing, and drying in an oven at 50°C, a white powdery solid is obtained, which is PEMAGMA polymer nanoparticles.

Embodiment 3

[0061] 1. Prepare PHGC-PSGMA nano antibacterial particles, comprising the following steps:

[0062] Add 1.0 g of the PSGMA polymer prepared in Example 1 into 5.0 g of deionized water, ultrasonically disperse, then add 1.0 g of polyhexamethylene monoguanidine hydrochloride (PHGC), stir, and heat to 60 ° C, 0.002 g of triethylamine catalyst was added, and the reaction was stopped after 48 hours. After centrifugal separation and washing for 5 times, drying in an oven at 50° C. to obtain a white powdery solid, which is PHGC-PSGMA nanometer antibacterial particles.

[0063] 2. Characterization of PHGC-PSGMA nano antibacterial particles and detection of antibacterial performance

[0064] PHGC was prepared as a solution, and PHGC-PSGMA was ultrasonically dispersed in water to obtain an emulsion.

[0065] 1) Utilize the dynamic light scattering method to record the average particle diameter of the nano-microspheres in the PHGC-PSGMA emulsion to be 172.9nm, while the average particle...

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Abstract

The invention discloses guanidyl macromolecule antibacterial nano microspheres and a preparation method thereof. The preparation method comprises preparation steps as follows: vinyl type monomers and GMA (glycidyl methacrylate) are subjected to soap-free emulsion polymerization, a P-GMA copolymer is obtained, then a copolymer emulsion reacts with polyhexamethylene guanidine hydrochloride or polyhexamethylen biguanid hydrochloride under the catalytic action of triethylamine, and finally, the guanidyl macromolecule antibacterial nano microspheres are obtained through centrifugal separation, washing and drying. The prepared antibacterial nano microspheres take water-soluble polyhexamethylene guanidine hydrochloride or polyhexamethylen biguanid hydrochloride as a shell, take a hydrophobic copolymer as a core, are easily dispersed in water and have an excellent sterilization effect. According to the method, a soap-free emulsion polymerization mode is adopted, and water is taken as a solvent, so that the method is environment-friendly, economical, effective and simple in process.

Description

technical field [0001] The invention relates to the field of functional polymer materials. More specifically, it relates to a guanidine-based polymer antibacterial nano-microsphere and a preparation method thereof. Background technique [0002] Polyguanidine salt is often used for antibacterial treatment, especially in aqueous solution. Due to its low biological toxicity and little damage to biological cells, it has been widely used in antibacterial and antifungal of crops, disinfection and antisepsis in the field of medicine and health, antisepsis in cosmetics and In the antibacterial finishing of textiles, it is also widely used in the field of aquaculture. Due to the good water solubility and strong hygroscopicity of polyguanidine salt, its application in plastics, fibers, rubber and coatings is limited. The application of polyguanidine in plastics has received extensive attention in recent years, but during the melting process of polyguanidine salt, it is easy to appea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/02C08F212/08C08F220/32B01J13/14
CPCB01J13/14C08F212/08C08G81/024C08F220/325
Inventor 季君晖孙潇潇甄志超
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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