A Depth Correction Method for Optical Resolution Photoacoustic Microtomography Three-dimensional Tomography
A technology of photoacoustic microscopy and three-dimensional tomography, applied in the field of biomedical photonics diagnosis, can solve the problems of adjuvant therapy, affecting the three-dimensional reconstruction of the measured bio-photoacoustic, unable to detect the images of lesions or damaged tissues, etc. Accuracy, improved precision, the effect of improved resolution
Inactive Publication Date: 2021-08-24
JIANGXI SCI & TECH NORMAL UNIV
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If there is a diseased or damaged tissue in a depth far from the ultrasonic probe, the photoacoustic signal detected by it may be smaller than the photoacoustic intensity obtained on a layer of tissue where the photoacoustic source is closer to the ultrasonic probe. As a result, the photoacoustic signal originally intended to reflect the diseased tissue is submerged by the photoacoustic signal closer to the ultrasonic probe, which will inevitably seriously affect the photoacoustic 3D reconstruction of the internal lesion or damaged tissue of the tested organism, thus making it impossible to correctly image the detected tissue. Detect lesions or damaged tissues for clear images to assist treatment
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Embodiment 1
[0033] For a certain body-like tissue, two carbon fibers are implanted in the body-like tissue to obtain the tested sample. According to steps (1) and (2), the sample is placed horizontally on the ultrasonic probe with the ultrasonic coupling liquid evenly applied in the front section, and then the parameters of the three-dimensional scanning platform are set as follows: The moving length (respectively being Lx=4.5mm, Ly=4.5mm and Lz=4.5mm) that the stepper motor moves, the moving step size are 0.025mm, and the moving steps (respectively being s=180, k=180 and n= 180), that is: in the X, Y and Z directions, the ranges of the moving steps of the three stepping motors are: 1,2,...,180; 1,2,...,k and 1,2,...,180 .
[0034] Then, operate according to steps (3) to (5) proposed in the present invention. First, the photoacoustic amplitude matrix data of the measured sample on the first depth plane (S1), the second depth plane (S2) and the third depth plane (S3) can be obtained, suc...
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The invention discloses a depth correction method for optical resolution photoacoustic microscopic three-dimensional tomography. The average value of photoacoustic amplitude obtained on the first depth plane is used as a reference, and the average value of photoacoustic amplitude obtained on each depth plane is used as a reference. Comparing with the benchmark and obtaining the difference, and then subtracting the corresponding difference on each depth plane from the real-time photoacoustic amplitude obtained on each depth plane, the depth-corrected measured tissue on each depth plane can be obtained. Finally, the 2D and 3D image reconstruction algorithms are used respectively to obtain the 2D photoacoustic image of the measured tissue on a certain depth plane and the 3D photoacoustic image of the entire measured tissue after depth correction. . Compared with the existing photoacoustic imaging, the method proposed by the present invention has the characteristics of convenience, quickness, and easy implementation. At the same time, the method proposed by the invention is applicable to photoacoustic detection and imaging systems including forward, backward and side detection modes.
Description
technical field [0001] The invention belongs to the technical field of biomedical photonics diagnosis, and in particular relates to a depth correction method for optical resolution photoacoustic three-dimensional tomography. Background technique [0002] In biomedical diagnosis, it is usually necessary to image the tissues and lesions in the living body for adjuvant treatment. At present, the commonly used detection methods are: X-ray radiography, X-CT, nuclear magnetic resonance and PET imaging, etc., but most of these detection methods use light with radioactive elements. If you are exposed to these radioactive elements for a long time, in a certain To a certain extent, it will also have pathogenic effects on normal biological tissues such as the human body. Photoacoustic technology is a new type of biomedical photonics detection technology, which combines the advantages of optics and ultrasound. It uses short-pulse visible light or near-infrared light as an excitation li...
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IPC IPC(8): G01N21/17G01N29/24G01N29/44
CPCG01N21/1702G01N29/2418G01N29/4463G01N2291/02483
Inventor 任重刘国栋熊志华
Owner JIANGXI SCI & TECH NORMAL UNIV