Unlock instant, AI-driven research and patent intelligence for your innovation.

Categorization data manipulation using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer

A mass spectrometer and reference data technology, which is applied in the field of classification data manipulation using matrix-assisted laser desorption/ionization time-of-flight mass spectrometer, can solve problems such as complexity

Pending Publication Date: 2019-08-16
HIGHLAND INNOVATIONS INC
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Complicating issues can arise when comparing a test sample to reference data for efficient and / or effective characterization of the test sample

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Categorization data manipulation using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer
  • Categorization data manipulation using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer
  • Categorization data manipulation using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] Exemplary figure 1 A disease diagnostic laboratory according to an embodiment is shown, wherein a sample processing facility 101 comprises a plurality of sample processing tools, a MALDI-TOF MS system 102 and a diagnostic software system 103 separated from each other. For example, to extract glycans for ovarian cancer diagnosis, patient's serum is added to a multi-well plate 111 for a sample receiving process and a protein denaturation process 112, followed by a deglocosylation process 113 using enzymes. Then, a protein removal process 114 , a drying and centrifugation process, a glycan extraction process 115 and a spotting process 116 are performed. MALDI-TOF MS system 102 analyzes the spotted sample to generate at least one glycan profile. The diagnostic software 103 compares the glycan profile of the sample to one or more pre-stored glycan profiles to determine the presence and progression of ovarian cancer.

[0024] Exemplary figure 2 is an integrated disease di...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to methods, systems, apparatuses, and / or computer programs. Mass spectrometer test data (e.g. a blood sample of a medical patient) may be associated with metadata information. The associated metadata information may be associated with the medical patient. A subset of a sample reference library may be based on the associated metadata information. The sample reference library may include a plurality of sets of mass spectrometer reference data, in accordance with embodiments. Embodiments match the mass spectrometer test data with mass spectrometer reference data of the selected subset of the sample reference library. Embodiments determine characteristic information of a source of the mass spectrometer test data (e.g. the medical patient) based on the known characteristics of the matched mass spectrometer reference data.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 377,768, filed August 22, 2016, the entire contents of which are hereby incorporated by reference. Background technique [0003] Biomarkers are biological molecules present in blood, other bodily fluids or tissues that are markers of the normal or abnormal course of a disorder and / or disease. For example, the glycoprotein CA-125 is a biomarker that can indicate the presence of cancer. Thus, biomarkers can be measured and evaluated to identify the presence or progression of a particular disease or to see how well the body is responding to treatment for a disease or condition. The presence and / or changes in the quantitative levels of biomarkers in proteins, peptides, lipids, glycans and / or metabolites can be measured by a mass spectrometer. [0004] Among the many types of mass spectrometers, matrix-assisted laser desorption / ionization time-of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B01D59/44G01N30/00G01N31/00G16H50/20G06Q10/00H01J49/00G06N20/00
CPCG06N20/00H01J49/0036G16H50/20H01J49/0418G06F16/355H01J49/26H01J49/28G06F16/14A61B5/7246
Inventor 赵英俊赵邀韩
Owner HIGHLAND INNOVATIONS INC