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Endometriosis diagnosis and prognosis marker and application thereof

A prognostic marker, endometrium technology, applied in the medical field, can solve the problems of high recurrence risk and increased infertility rate

Pending Publication Date: 2019-08-20
辽宁省肿瘤医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, due to its unique biological development characteristics, the risk of recurrence after clinical surgery is high, and the infertility rate increases

Method used

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  • Endometriosis diagnosis and prognosis marker and application thereof
  • Endometriosis diagnosis and prognosis marker and application thereof
  • Endometriosis diagnosis and prognosis marker and application thereof

Examples

Experimental program
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Embodiment

[0034] Specimen selection.

[0035] A total of 32 patients (43.38±5.01 years old) who underwent hysterectomy due to ovarian endometriosis were selected, and their paired eutopic endometrium (Eu) and ectopic endometrium (Ec) were collected as an experiment. During the same period, 31 patients (43.74±4.69 years old) who underwent hysterectomy due to cervical intraepithelial neoplasia were selected, and their endometrium (eutopic normal endometrium, EN) was collected as the control group. Both groups had regular menstruation, were not associated with other medical or surgical diseases, and did not receive hormone therapy 6 months before operation. All cases were diagnosed by postoperative pathology. This study was approved by the Ethics Committee of Liaoning Cancer Hospital. Fresh specimens were divided into three parts after isolation: part was fixed with 10% neutral formaldehyde and embedded in paraffin; part was immediately placed in liquid nitrogen and frozen in a -80°C ref...

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Abstract

The invention discloses an endometriosis diagnosis and prognosis marker and an application thereof. The marker is characterized in that the marker is miR-126-5p or BCAR3 (Breast cancer anti-estrogen resistance 3). The BCAR3 is applied to the preparation of a kit used for the diagnosis and / or prognosis evaluation of endometriosis. The BCAR3 is a biomarker for evaluating the risk of the endometriosis disease. The miR-126-5p or BCAR3 recombinant virus vector is applied to the preparation of products with the function of inhibiting endometriosis. The miR-126-5p or BCAR3 recombinant virus vector isused for preparing medicaments for preventing and / or treating endometriosis. The miR-126-5p and BCAR3 provided by the invention can be used as a novel biomarker to be applied to diagnosis and / or prognosis evaluation of endometriosis; and the corresponding miR-126-5p agomir and BCAR3 recombinant lentiviral vector can be used as a novel medicament, and have potential prevention and treatment valuesfor endometriosis.

Description

technical field [0001] The invention belongs to the field of medicine and biotechnology, and specifically relates to the application of BCAR3 gene as a diagnosis, prognosis, marker and therapeutic drug of endometriosis. Intrauterine Diagnosis and assessment of disease progression. Background technique [0002] Endometriosis (endometriosis, EMs, referred to as endometriosis) is a common and refractory disease in gynecology. Although it is a benign disease dependent on estrogen, it has widespread distribution of lesions, various forms, local invasion, and distant metastasis. And recurrence and other biological behaviors similar to malignant tumors. There are different opinions on the pathogenesis of endometriosis, among which the "menstrual blood reflux theory" is a classic theory to explain its pathogenesis, but what cannot be explained is that menstrual blood reflux is a common physiological phenomenon in women of childbearing age, with an incidence rate of about 90%, while...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12N15/113A61K31/7105A61P15/00
CPCC12Q1/6883A61K31/7105A61P15/00C12Q2600/178C12Q2600/158C12Q2600/118
Inventor 王丹波
Owner 辽宁省肿瘤医院
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