Method for preparing coated medical burning adhesion-prevention type gauze bandage, as well as product and application of coated medical burning adhesion-prevention type gauze bandage

An anti-adhesion and gauze technology, applied in bandages, pharmaceutical formulations, textiles and papermaking, etc., can solve the problems of using non-specific protein burn dressings, reducing blood compatibility, affecting thrombus formation, etc., and achieve good bone growth-promoting performance, Effect of improving mechanical properties and good biocompatibility

Inactive Publication Date: 2019-08-30
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cotton gauze bandage material is used as an auxiliary material for first aid and postoperative wound healing operations. It can provide a clean and moist microscopic environment for the wound, provide physical support, and protect the wound surface. However, the adsorption of non-specific proteins on the surface of cotton gauze materials Cannot be used directly as a burn dressing
When the blood contacts the material, the plasma protein will be adsorbed to the surface of the material in less than 1 second to form a protein adsorption layer, which will cause the adsorption of a large number of platelets, thereby indirectly affecting the formation of thrombus, resulting in a decrease in the blood compatibility of the material

Method used

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  • Method for preparing coated medical burning adhesion-prevention type gauze bandage, as well as product and application of coated medical burning adhesion-prevention type gauze bandage
  • Method for preparing coated medical burning adhesion-prevention type gauze bandage, as well as product and application of coated medical burning adhesion-prevention type gauze bandage
  • Method for preparing coated medical burning adhesion-prevention type gauze bandage, as well as product and application of coated medical burning adhesion-prevention type gauze bandage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A film-coated medical burn antibacterial and anti-adhesion gauze bandage. The main structure is an ordinary veil bandage as a mechanical support layer. The bandage veil fibers are activated by surface treatment and coated with an adhesive. The surface of the material is constructed of polycaprolactone-polylactide copolymer (PCL-PDLLA polymer) hydrophobic fiber layer to avoid direct contact between the original gauze cotton fiber and the skin, and the plasma liquid components gushed out of the wound are absorbed by the cotton fiber through the fine and interlaced holes , the blood cells and protein components are blocked by the fiber layer and will not stick to the spinning layer. The schematic diagram of preparing the composite hydrophobic film layer gauze is as follows figure 1 Shown, prepared as follows:

[0038] Mix 0.2g of PCL-PDLLA with 2g of hexafluoroisopropanol, ultrasonicate for 30 minutes, and magnetically stir overnight to obtain a homogeneous solution of PCL...

Embodiment 2

[0041]A film-covered medical burn antibacterial anti-adhesion type gauze bandage is prepared according to the following steps:

[0042] Mix 0.2g of PCL-PDLLA and 2g of hexafluoroisopropanol at a mass ratio of 0.1:1, ultrasonicate for 30 minutes, and magnetically stir overnight to obtain a uniform solution of PCL-PDLLA / hexafluoroisopropanol with a mass concentration of 9%. Add 0.5% (HAp:PCL-PDLLA mass ratio) of HAp and continue to sonicate for 30 minutes; stir at room temperature for 12 hours to obtain a PCL-PDLLA / Hap / hexafluoroisopropanol solution; fill the resulting solution into a 10 mL glass syringe Inside, the equipment and conditions of electrospinning are the same as in the examples, covering the gauze on the aluminum foil and laying it on the receiver; at the spinning voltage of 15 KV, the spinning receiving distance is 10 cm, the diameter of the needle is about 0.1 mm, and the solution flow rate Under the condition of 0.4 mL / h, the composite nanofiber membrane composit...

Embodiment 3

[0045] A film-covered medical burn antibacterial anti-adhesion type gauze bandage is prepared according to the following steps:

[0046] Mix 0.2g of PCL-PDLLA and 2g of hexafluoroisopropanol at a mass ratio of 0.1:1, ultrasonicate for 30 minutes, and magnetically stir overnight to obtain a uniform solution of PCL-PDLLA / hexafluoroisopropanol with a mass concentration of 9%. Add 1% (HAp:PCL-PDLLA mass ratio) of HAp, and continue to sonicate for 30 minutes; stir at room temperature for 6~12h to obtain a PCL-PDLLA / Hap / hexafluoroisopropanol solution; put the resulting solution into a 10 mL In the glass syringe, cover the gauze on the aluminum foil and lay it on the receiver. The electrospinning process conditions are the same as in Example 1. The spinning voltage is 15KV, the spinning receiving distance is 10 cm, the needle diameter is about 0.1mm, and the solution flow rate Under the condition of 0.4 mL / h, the composite nanofiber film composite gauze was obtained by electrospinnin...

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Abstract

The invention relates to a method for preparing a coated medical burning adhesion-prevention type gauze bandage, as well as a product and application of the coated medical burning adhesion-preventiontype gauze bandage. A conventional gauze bandage is used as a mechanical supporting layer for a main body structure, the bandage gauze fibers are activated through surface treatment and are coated with binder, and a polycaprolactone-polylactide copolymer (PCL-PDLLA polymer) and PCL-PDLLA polymer / inorganic nanoparticle hydrophobic layer is constructed on the surface of the gauze material by an electrostatic spinning method, the cotton fibers of the raw gauze is prevented from being directly contacted with skin, liquid components of plasma gushing from a wound can be absorbed by the cotton fibers through fine and staggered holes, and hemocytes and protein components are stopped by the fiber layer and cannot adhere to the spinning layer.

Description

technical field [0001] The invention relates to a gauze bandage material used in surgical burn operations and wound bandaging, and belongs to the application field of medical device preparation and processing. [0002] technical background [0003] The destruction of the skin barrier effect of burns on the human body will cause serious human damage. The biggest feature of burn wounds is that they are dry and easy to scab, easy to stick to the dressing, easy to infect and difficult to heal, so it is important to find a suitable auxiliary material to control wound infection and promote wound healing. extremely important. Cotton gauze bandage material is used as an auxiliary material for first aid and postoperative wound healing operations. It can provide a clean and moist microscopic environment for the wound, provide physical support, and protect the wound surface. However, the adsorption of non-specific proteins on the surface of cotton gauze materials It cannot be used dire...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/42A61L15/18A61L15/62D01D5/00
CPCA61L15/18A61L15/26A61L15/42A61L15/425A61L15/62A61L2400/12D01D5/003D01D5/0084C08L67/04
Inventor 何丹农严一楠杨迪诚王杰琳王萍徐艳金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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