Triterpene compounds as well as preparation method and application thereof
A technology for compounds and triterpenoids, applied in the application field of preparing anticancer drugs, can solve the problems of few reports on the anticancer activity of the chemical constituents of Amaryllis emblica, and achieve a remarkable inhibitory effect, a simple and easy preparation method, and a significant effect. Effect
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Embodiment 1
[0026] 1. Preparation of compounds
[0027] Step 1. Take 15 kg of dried emblica root as a raw material, cut into pieces and pulverize, add 100 L of 95% ethanol to soak three times, filter under reduced pressure after soaking for 2 to 3 days each time, combine the recovered filtrate, and continue to soak the filter residue with 95% ethanol. Obtain 2.67kg of medicinal extract extract without alcohol taste;
[0028] Then dissolve the extract of the extract in 8L of distilled water to form a suspension, extract with 8L of ethyl acetate solvent, mix well and let it stand overnight after contacting, after layering, take the upper ethyl acetate layer, and the lower water layer continues Add ethyl acetate equal to the volume of the remaining distilled water for extraction, and after repeated extraction three times, combine the collected ethyl acetate layers to obtain 1.54 kg of ethyl acetate extract;
[0029] Step 2. Then heat and dissolve the ethyl acetate extract with 3L, 95% ethan...
Embodiment 2
[0043] Compound preparation
[0044] Step 1. After drying the fresh emblica cotyledon in the sun, take 10kg of dried emblica cotyledon as raw material, crush it, add 50L, 95% ethanol to soak three times, filter under reduced pressure after soaking for 2-3 days each time, combine the recovered filtrate and filter residue Continue to soak with 95% ethanol to obtain 2.45kg of extract of medicinal extract without alcohol smell;
[0045] Then dissolve the extract of the extract in 5L of distilled water to form a suspension, extract with 5L of ethyl acetate solvent, mix well and let it stand overnight after contacting, after layering, take the upper ethyl acetate layer, and the lower water layer continues Add ethyl acetate equal to the volume of the remaining distilled water for extraction, and after repeated extraction three times, combine the collected ethyl acetate layers to obtain 1.33 kg of ethyl acetate extract;
[0046] Step 2. Then heat and dissolve the ethyl acetate extrac...
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