Application of artificial joint prosthesis with biomimetic function in preparation of large segmental bone defect reconstruction material

A technology for artificial joints and bionic functions, applied in prostheses, joint implants, joint implants, etc., can solve problems such as severe wear and large wear debris, achieve mature preparation technology, controllable pore size, and avoid local effects of trauma

Inactive Publication Date: 2019-09-10
SHANGHAI CHANGZHENG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, UHMWPE wears seriously in the late stage and often produces a lot of wear debris

Method used

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  • Application of artificial joint prosthesis with biomimetic function in preparation of large segmental bone defect reconstruction material
  • Application of artificial joint prosthesis with biomimetic function in preparation of large segmental bone defect reconstruction material
  • Application of artificial joint prosthesis with biomimetic function in preparation of large segmental bone defect reconstruction material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 Artificial joint prosthesis of the present invention

[0032] One, the structure of artificial joint prosthesis of the present invention

[0033] The artificial joint prosthesis with bionic function of the invention is composed of a porous layer, a compact layer and an embedded layer. Such as Figure 1-Figure 3 As shown, among them, figure 1 and figure 2 Indicates the positional relationship, proportional relationship between different layers and the internal structure of each layer, image 3 Indicates the shape of the artificial joint that is actually produced, and the size of the artificial joint can be adjusted according to the specific conditions of the patient.

[0034] 1. Porous layer

[0035] The porous layer is the contact part of the articular surface, designed as a porous structure, and the material used is nano-hydroxyapatite / polyamide 66. The porosity of the porous structure is 85% to 90%, the inner diameter of the pores is 200 to 350 μm,...

experiment example 1

[0048] Experimental Example 1: Different Pore Sizes of Porous Layers to Cultivate Chondrocyte Layers

[0049] The artificial joint prosthesis prepared by the method of the present invention is taken, inoculated with cells, and cultured.

[0050] Experimental results show that the specific porosity and inner diameter in the porous structure of the porous layer of the present invention are beneficial to the cultivation of the chondrocyte layer.

experiment example 2

[0051] Experimental Example 2 Application of Artificial Joint Prosthesis in Reconstruction of Large Segmental Bone Defect

[0052] The artificial joint prosthesis prepared by the method of the present invention is used for bone defect reconstruction.

[0053] The experimental results show that the cultivation of the chondrocyte layer on the porous structure of the present invention is beneficial to the realization of the motor function; the macroporous structure added to the dense layer is filled with autologous bone tissue, so that the artificial joint prosthesis and the surrounding bone tissue "grow" as one, which can realize Good bone tissue fusion, autologous bone tissue vascularization and better supporting function.

[0054] In summary, the present invention provides an artificial joint prosthesis with bionic function in the reconstruction of large bone defects. The artificial joint prosthesis utilizes specific nano-hydroxyapatite / polyamide 66 materials, combined with T...

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Abstract

The invention discloses an application of an artificial joint prosthesis with a biomimetic function in preparation of a large segmental bone defect reconstruction material, and the artificial joint prosthesis with the biomimetic function is composed of a porous layer, a compact layer and an embedding layer. The artificial joint prosthesis combines a special design of the porous layer, the compactlayer and the embedding layer of the invention by utilizing a specific nano hydroxyapatite / polyamide 66 material, for example, due to a design of a pore structure in the porous layer and cultivation of a chondrocyte layer on a porous structure to form an articular cartilage surface, a motion function is achieved; for another example, a large pore structure is added in the compact layer to fill autologous bone tissue, so that the artificial joint prosthesis "grows" with surrounding bone tissue into one body; and therefore, the artificial joint prosthesis with the biomimetic function and used for large segmental bone defect reconstruction is obtained and prepared, complications of loosening and sinking of the prosthesis are reduced, and the service life of an artificial joint is prolonged.

Description

technical field [0001] The invention relates to the application of an artificial joint prosthesis with bionic function in preparing large-segment bone defect reconstruction materials. Background technique [0002] Trauma, tumors, chronic inflammation and other diseases can cause bone defects in the human body. Larger bone defects need to be implanted in clinical treatment. Artificial joint prosthesis replacement has been widely used in clinical practice and achieved good clinical results. However, with the passage of time, complications such as prosthesis loosening and sinking caused by this operation have become increasingly prominent, seriously affecting the clinical efficacy of the operation and the quality of life of the patient. Once patients have these adverse outcomes, patients often need to undergo revision surgery, which not only increases the patient's surgical pain and medical expenses, but also the clinical efficacy after revision is far less ideal than the initi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/30A61L27/46A61L27/38A61L27/50A61L27/56
CPCA61F2/30771A61F2002/30772A61L27/3817A61L27/46A61L27/50A61L27/56A61L2430/24C08L77/06
Inventor 刘铁龙胡一为白广建高欣王静刘永刚陈广辉汪洋刘戈曹佳实刘伟波杨家祥董连峰信保全吕凯
Owner SHANGHAI CHANGZHENG HOSPITAL
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