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Janus particles with compatibility and preparation method thereof

A technology of biocompatibility and granules, which is applied in the field of Janus granules and its preparation, can solve problems such as limited applications, and achieve good biocompatibility, good biodegradability, and simple and easy methods

Active Publication Date: 2019-09-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no biocompatible Janus particles, which greatly limits its application in food, cosmetics, etc.

Method used

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  • Janus particles with compatibility and preparation method thereof
  • Janus particles with compatibility and preparation method thereof
  • Janus particles with compatibility and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Preparation of biocompatible Janus particles with a particle size of about 400 nm

[0048]With reference to accompanying drawing 1 (a), adopt the method of the present invention to prepare the Janus particle with biocompatibility, concrete steps are as follows:

[0049] (1) Dissolve 120mg of shellac in 5ml of tetrahydrofuran, put it into the rotor and stir on a magnetic stirring table until the shellac is completely dissolved to obtain a shellac solution with a concentration of 24mg / ml; then dissolve 120mg of polylactic acid in the shellac solution , ultrasonically dispersed to obtain a mixed solution with a shellac concentration of 24 mg / ml and a polylactic acid concentration of 24 mg / ml. Add 1ml of Tween 80 to 100ml of deionized water, ultrasonically disperse in an ultrasonic cleaner, and then filter with a disposable syringe filter (specification: Φ25mm*0.45μm) to obtain an aqueous solution of Tween 80.

[0050] (2) Heat the mixed solution prepared in ste...

Embodiment 2

[0052] Embodiment 2: Janus particles in the particle shape change process in alkaline solution

[0053] (1) Dissolve 150mg of shellac in 5ml of tetrahydrofuran, put it into the rotor and stir on a magnetic stirring table until the shellac is completely dissolved to obtain a shellac solution with a concentration of 30mg / ml; then dissolve 150mg of polylactic acid in the shellac solution , ultrasonically dispersed to obtain a mixed solution with a shellac concentration of 30 mg / ml and a polylactic acid concentration of 30 mg / ml. Add 1ml of Tween 80 to 100ml of deionized water, ultrasonically disperse in an ultrasonic cleaner, and then filter with a disposable syringe filter (specification: Φ25mm*0.45μm) to obtain an aqueous solution of Tween 80.

[0054] (2) Heat the mixed solution prepared in step (1) and 3ml of Tween 80 aqueous solution in a constant temperature water bath, set the temperature of the water bath to 70°C, heat for 15min, and take 100 μl of the mixed solution prep...

Embodiment 3

[0058] Embodiment 3: Regulate the size of Janus particle by changing the initial concentration of material

[0059] (1) According to the steps of Example 1, change the concentration of shellac and polylactic acid in tetrahydrofuran, but keep the concentration of shellac and polylactic acid the same, set the following groups of concentrations: 2mg / ml, 6mg / ml, 12mg / ml ml, 18mg / ml, 24mg / ml, and 30mg / ml were used to prepare Janus particles with the same volume as the shellac hemisphere and the polylactic acid hemisphere, but the overall size of the particle changes within the range of hundreds of nanometers, as shown in the attached image 3 shown.

[0060] (2) the Janus particles of different sizes prepared in step (1) are used to measure particle size distribution by DLS method, and the results are as follows:

[0061] When the concentrations of shellac and PLA are both 2mg / ml, the average particle size of Janus particles is about 230nm;

[0062] When the concentrations of she...

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Abstract

The invention discloses Janus particles with compatibility and a preparation method thereof. According to the preparation method, biocompatible materials are adopted, and lac and polylactic acid materials are dissolved in a common good solvent; then, the mixed solution is rapidly injected into an aqueous solution containing a surfactant at a certain temperature; and based on the coprecipitation and phase separation mechanism, lac-polylactic acid Janus nanoparticles with lac at one end and polylactic acid at the other end are obtained. By adjusting the concentration of lac and polylactic acid in the good solvent, size of the Janus nanoparticles can be regulated. By adjusting the ratio of lac to polylactic acid in the good solvent, proportions of lac hemispheres and polylactic acid hemispheres can be regulated. Through interaction of positive and negative charges, the surface of the lac hemispheres is modified with polylysine having biocompatibility, thus enhancing hydrophilicity of thelac hemispheres. The Janus nanoparticles with compatibility have amphipathy, and can greatly stabilize an oil-in-water emulsion when being used as a particle surfactant.

Description

technical field [0001] The invention relates to the field of granular materials, in particular to a Janus particle with biocompatibility and a preparation method thereof. Background technique [0002] Emulsion has broad application prospects in food, cosmetics and other fields. Emulsions include water-in-oil emulsions in which the water phase is dispersed in the oil phase and oil-in-water emulsions in which the oil phase is dispersed in the water phase. Stabilization of emulsions usually requires the addition of surfactants. Traditional surfactants are amphiphilic molecules with both hydrophilic and hydrophobic groups, which can effectively reduce the tension at the water / oil interface. However, traditional molecular surfactants are in a dynamic equilibrium of adsorption and desorption at the interface due to thermal motion, and droplets are prone to fusion. On the other hand, under the influence of Ostwald ripening, small droplets will gradually become smaller and large ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/04C08J3/14B01F17/52C08L93/02C08L67/04C08L77/04C09K23/52
CPCC08J3/14C08J2393/02C08J2367/04C08J2477/04C09K23/16C09K23/018C08J7/0427
Inventor 陈东孙竹吴柏衡孔琳琳
Owner ZHEJIANG UNIV
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