Substituted polycyclic pyridone compound and prodrug thereof

A compound and solvent compound technology, applied in heterocyclic compound isotope introduction, isotope introduction into organic compounds, organic chemistry, etc., can solve problems such as limited application range, poor patient compliance, and unmet clinical needs
CN110317211AActive Publication Date: 2019-10-11SHENZHEN TARGETRX INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENZHEN TARGETRX INC
Publication Date
2019-10-11

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Abstract

The invention provides a deuterium-substituted polycyclic pyridone compound, a prodrug thereof, a composition containing the compound and application of the composition. The deuterium-substituted polycyclic pyridone compound is the compound shown in the formula (I) or a tautomer, stereoisomer, prodrug, crystalline form, pharmaceutically acceptable salt, hydrate or solvent compound thereof. The compound and the composition show the cap-dependent endonuclease inhibitory activity and have superior pharmacokinetic properties.
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Description

technical field

[0001] The present invention relates to a substituted polycyclic pyridone compound and its prodrug, a composition containing the compound and its application. More specifically, the present invention relates to certain deuterium-substituted (((12aR)-12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(B,E)thiaheptine -11-yl)-6,8-dioxo-3,4,6,8,12,12a-hexahydro-1H-(1,4)oxazine(3,4-C)pyrido(2, 1-F) (1,2,4) triazin-7-yl) oxy) methyl methyl carbonate and parent drug thereof, these deuterium-substituted compounds and compositions thereof exhibit cap-dependent endonuclease ( Cap-dependent endonuclease) inhibitory activity, and these deuterium-substituted compounds have better pharmacokinetic properties. Background technique

[0002] Influenza is called influenza (influenza or flu) for short, is the acute respiratory infectious disease that is caused by the infection of influenza virus, has become the viral infectious disease with the highest fatality rate. Elderly people o...

Claims

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