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Cydonia oblonga-ocimum basilicum total flavonoid composition and application thereof in atherosclerosis

A technology of total flavonoids and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, plant raw materials, etc., and can solve problems such as no atherosclerosis

Active Publication Date: 2019-10-15
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no technical status about the combination of quinces and basil total flavonoids for the treatment of atherosclerosis in the prior art

Method used

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  • Cydonia oblonga-ocimum basilicum total flavonoid composition and application thereof in atherosclerosis
  • Cydonia oblonga-ocimum basilicum total flavonoid composition and application thereof in atherosclerosis
  • Cydonia oblonga-ocimum basilicum total flavonoid composition and application thereof in atherosclerosis

Examples

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Effect test

Embodiment 1

[0034] The present invention specifically provides a quince-basil total flavonoid composition, which comprises 1-3 parts of quince total flavonoids and 1-3 parts of basil total flavonoids in parts by weight.

Embodiment 2

[0036] On the basis of the specific prescription of the quince-basil total flavonoids composition provided in Example 1, the preparation method of the quince-basil total flavonoids composition specifically adopts the following technical steps:

[0037] Simultaneously, the present invention provides the preparation method of above-mentioned quince-basil total flavonoid composition, specifically adopts the following technical steps:

[0038] (1) Extraction and separation of total flavonoids of quinces, cut quinces fruit into small pieces, dry naturally at room temperature, degrease with petroleum ether, dry the dregs in vacuum, and extract the dried dregs with ethanol twice, 1 hour each time, The extract is filtered, the filtrates are combined twice, concentrated under reduced pressure to an extract, redissolved with an appropriate amount of distilled water, extracted twice with 3-6 times the amount of chloroform, the chloroform layer is removed, and the water layer is concentrat...

Embodiment 3

[0049] Based on the preparation method of the quince-basil total flavonoids composition provided by the above-mentioned Example 2, the quince-basil total flavonoids composition comprises 1 part of quinces total flavonoids and 1 part of basil total flavonoids in parts by weight.

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Abstract

The invention discloses a cydonia oblonga-ocimum basilicum total flavonoid composition and application thereof in atherosclerosis. The cydonia oblonga-ocimum basilicum total flavonoid composition comprises the following components in parts by weight: 1-3 parts of cydonia oblonga total flavonoid and 1-3 parts of ocimum basilicum total flavonoid. A test of the cydonia oblonga-ocimum basilicum totalflavonoid composition for atherosclerotic rats shows that: the cydonia oblonga-ocimum basilicum total flavonoid composition can effectively reduce blood fat and blood vessel injury factor level, increase antioxidant enzyme level, improve organism oxidation resistance, reduce oxide formation, increase blood vessel protection factor level, effectively protect blood vessel, improve liver function andprevent lipid metabolism disorder. The synergistic effect of the cydonia oblonga-ocimum basilicum total flavonoid composition improves the curative effect on atherosclerosis, and further provides a theoretical basis for preventing and treating atherosclerosis.

Description

technical field [0001] The present invention mainly relates to the technical field of application of total flavonoids, in particular, the present invention relates to a quince-basil total flavonoid composition and the technical field of its application in atherosclerosis. Background technique [0002] Atherosclerosis (AS) is a common cardiovascular disease with high incidence and serious impact on human health. It is not only a lesion of the artery itself, but also the main cause of myocardial infarction, cerebral infarction, gangrene and loss of limb function, and is the main pathological basis of cardiovascular and cerebrovascular diseases. The related complications caused by AS are the direct cause of the increased mortality of cardiovascular and cerebrovascular diseases, and more and more people pay attention to it. Combination medication refers to the combination of two drugs with similar effects and effects for the same disease to effectively prevent and treat the occ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P9/10A61K36/53
CPCA61K36/53A61K36/73A61K2236/333A61K2236/35A61K2236/39A61K2236/51A61K2236/55A61P9/10A61K2300/00
Inventor 艾尼瓦尔·吾买尔周文婷阿迪力·阿不都热合曼阿布来提·阿布力孜艾合麦提江·纳曼阿尔祖亚·多力空阿迪拉·迪里夏提艾再提·克热木阿地力江·萨吾提吉米丽汗·司马依
Owner XINJIANG MEDICAL UNIV
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