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Blood oxcarbazepine drug concentration monitoring kit and detection method thereof

A technology for drug concentration and kits, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of high technical requirements for experimenters, inaccurate qualitative and quantitative, and complicated pretreatment, so as to reduce errors and personnel operation errors, detect The process is simple and fast, and the effect of reducing the experimental cost

Inactive Publication Date: 2019-10-22
苏州艾迪迈医疗科技有限公司
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Problems solved by technology

Previous methods have problems such as complicated pre-treatment, inaccurate qualitative and quantitative results, high cost, long analysis time, or high technical requirements for experimenters.

Method used

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  • Blood oxcarbazepine drug concentration monitoring kit and detection method thereof
  • Blood oxcarbazepine drug concentration monitoring kit and detection method thereof
  • Blood oxcarbazepine drug concentration monitoring kit and detection method thereof

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Embodiment Construction

[0036] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further elaborated below in conjunction with illustrations and specific embodiments.

[0037] 1. Preparation of oxcarbazepine and its metabolite therapeutic drug monitoring kit:

[0038] Standard curve reagents: oxcarbazepine and its metabolites are formulated with animal serum containing 2% stabilizer and 2% plasticizer to prepare a series of concentrations, respectively 1.5mg / L, 3.0mg / L, 6.0mg / L, 14.0 mg / L, 27.0mg / L, 55.0mg / L, 1.0ml per bottle. The above components were freeze-dried and stored at the bottom of the assay bottle. Quality control reagents: Oxcarbazepine and its metabolites are formulated with animal serum containing 2% stabilizers and 2% plasticizers to three concentrations of 5.0mg / L, 25.0mg / L, and 45.0mg / L, 1.0ml per bottle. The above components were freeze-dried and stored at the bottom of t...

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Abstract

The invention relates to the field of medical detection and in particular to a blood oxcarbazepine and its metabolite therapeutic drug monitoring kit developed based on multi-dimensional online solid-phase extraction liquid chromatography analytical technology, more specifically to a method for accurately and quantitatively detecting oxcarbazepine and its metabolite drug concentration in blood byonline solid-phase extraction and multi-dimensional liquid chromatography analytical technology. The kit includes a calibration reagent, a quality control reagent, a processing liquid, an extract liquid, a washing liquid, and an eluent. The therapeutic drug monitoring kit of the invention only needs to centrifuge a blood sample, achieves low repeated detection variability, high accuracy and stability, and low detection cost, has various methodological indicators that satisfy the requirement for monitoring the blood oxcarbazepine and its metabolite therapeutic drugs, and is easy to generalize.

Description

technical field [0001] The present invention relates to the field of medical testing, in particular to a kit for monitoring oxcarbazepine and its metabolites in blood, which is developed based on multidimensional on-line solid-phase extraction liquid chromatography analysis technology, more specifically on-line solid-phase extraction A method for accurate and quantitative monitoring of the drug concentration of oxcarbazepine and its metabolites in blood using multidimensional liquid chromatography analysis technology. Background technique [0002] The anticonvulsant effect of oxcarbazepine and its metabolites is mainly to block the voltage-dependent sodium channel in the brain, thereby blocking the transmission of epileptic electrical activity in the epileptic focus. The effective blood concentration of oxcarbazepine and its metabolites is 10-35mg / L, and when the blood concentration>35mg / L, the toxic and side effects will be enhanced. Common adverse reactions include fat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/16G01N30/34G01N30/86
CPCG01N30/06G01N30/16G01N30/34G01N30/8631
Inventor 石功名何伶秀孙丹
Owner 苏州艾迪迈医疗科技有限公司
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