Quinoline-aspidospermine bi-indole alkaloid compound and application thereof

Abstract

The invention discloses a quinoline-aspidospermine bi-indole alkaloid compound. The quinoline-aspidospermine bi-indole alkaloid compound has the structural formulas shown in a formula I and a formulaII (please see the specification for the formula I and the formula II), wherein R1-R4 are correspondingly selected from hydrogen, hydroxy, methoxyl, ethyoxyl, acetyl, alkyl hydrocarbon and halogen. The experiment proves that the compound has the anti-inflammatory activity, the compound provides a lead compound for development of an anti-inflammatory preparation, and development and utilization ofplant medicinal resources are facilitated.

Description

Technical field

[0001] The present invention relates to a class of quinoline-basatinine type bis-indole alkaloid compounds and their application in preparing anti-inflammatory drugs. Background technique

[0002] Inflammation is a common pathological process in the clinic, which can be born in tissues and organs of various parts of the body, mainly manifested as swelling, redness, heat, pain and dysfunction. After the inflammatory factors act on the body, on the one hand, it triggers tissue cells Damage causes degeneration and necrosis of local tissue cells; on the other hand, it induces the body's anti-disease function to increase, which is beneficial to eliminate inflammatory factors and repair damaged tissues, thereby making the body's internal environment, internal environment and external environment To achieve a new balance between the two, the regulation and treatment of inflammatory response is of great significance to human health. The inflammatory response in the body ...

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