Quinaine-quinoline type dimer indole alkaloid compound and its application

A technology of dipolybenzdole alkaloids and quercetin, applied in the directions of drug combination, organic chemistry, organic chemistry methods, etc.
CN110372732BActive Publication Date: 2021-04-30云南聚和生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
云南聚和生物科技有限公司
Publication Date
2021-04-30

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Abstract

The present invention discloses a quinine-quinoline type dimindole alkaloid compound as shown in formula I: wherein, R 1 selected from hydrogen, hydroxy, methoxy, ethoxy, amino, aliphatic, aliphatic amino, amide, halogen; R 2 selected from hydrogen, hydroxy, methoxy, ethoxy, amino, aliphatic, aliphatic amino, amide, halogen; R 3 Selected from hydrogen, hydroxyl, methoxyl group, ethoxyl group, amino group, aliphatic hydrocarbon group, aliphatic amino group, amide, halogen; the RAW 264.7 cell inflammation model induced by LPS in the present invention is effective on quinine-quinoline type dimindole biological Alkaline compounds were evaluated for their anti-inflammatory activity. The experimental results confirmed that the quinine-quinoline type dimindole alkaloid compound had anti-inflammatory activity, and the plant raw materials of Jingdongshan orange were easy to obtain, the price was low, and the alkaloid extraction process was simple; The quinine-quinoline type dimindole alkaloid compound has good development and application prospects in the preparation of anti-inflammatory drugs.
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Description

Technical field

[0001] The present invention relates to a white cooker-quinoline type diopolyne biologically alkali compound and its application in preparing anti-inflammatory drugs.Background technique

[0002] Inflammation is a common multi-occurred disease that threatens human health, mainly as swelling, red, hot, pain, dysfunction, is a vascular system's living tissue to deal with defense response, physical, chemical or organisms such as damage factor. Or exogenous stimuli can cause inflammation. Many diseases or even cancer may have inflammatory responses, and the regulation of inflammatory responses and the treatment is of great significance to human health. In vivo inflammation involves participation in various cells, macrophages are one of the most important cells that control the most important inflammation of the body. The cytokines such as NO, IL-6, and TNF-α produced during the inflammatory reaction are mainly derived from activated macrophages. When LPS stimulates normal cell...

Claims

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