Construction and storage method of biological tissue non-uniform porous scaffold based on B-spline body

Abstract

The invention discloses a construction and storage method of a biological tissue non-uniform porous scaffold based on a B-spline body. The method comprises steps of inputting a B spline body model, performing grid discretization on a parameter domain of the B spline body model, setting a scalar value for each grid point, selecting a three-variable B spline function to perform iterative fitting, and constructing a C value distribution field C (u, v, w); selecting a three-period minimal curved surface to define an implicit curved surface implicit function expression and generating a parameter domain porous structure; mapping the porous structure of the parameter domain into the B spline body to generate a non-uniform porous scaffold, judging whether the scaffold meets actual requirements ornot, and if not, locally modifying the C value distribution field to regenerate the non-uniform porous scaffold; and storing and printing the non-uniform porous scaffold model in a TDF file format. According to the method, accurate control over the porosity of the porous structure and local adjustment of the porosity are achieved through the C value distribution field, it is guaranteed that the interior of the stent model is smooth and continuous, surface units are complete, and meanwhile compared with a traditional STL format, the TDF format greatly reduces the storage space.

Description

technical field [0001] The invention relates to general computer-aided design and tissue engineering technology, in particular to a method for constructing and storing biological tissue heterogeneous porous scaffolds based on B-spline bodies. Background technique [0002] Tissue engineering technology is one of the hot technologies in the field of medical life sciences, which marks the advent of the era of replicating regenerative tissues and organs, and opens up a new world for the rise of regenerative medicine. With the in-depth study of cell nucleus molecular biology and the rapid development of material science and biotechnology, medical scientists, with the help of growth factors, culture human cells on tissue engineering scaffolds, and then transplant them into the body to repair or replace diseased tissues or Organs, with the continuous proliferation and differentiation of seed cells, the biomaterials of the scaffold are continuously degraded and absorbed, and finally...

AI Technical Summary

Problems solved by technology

[0008] Since the current porous structure design methods mainly include two types of methods, one is to generate porous scaffolds by mapping regular TPMS units to each hexahedron of the hexahedral mesh model. This method causes each TPMS unit to be independent, and the interior cannot Well continuous, the performance of the porous structure depends on the quality of the hexahedral grid, and the porosity of the porous structure is not easy to control. The second is to immerse the model in a large TPMS structure and extract the porous structure through the intersection operation. This method The TPMS unit of the porous structure generated by design is not complete on the surface of the model, and the broken structure will affect the mechanical properties of the model

Most importantly, the porous scaffold files generated by the above methods are all saved in STL format, which greatly consumes storage space

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