Construction and storage method of heterogeneous porous scaffolds for biological tissues based on b-splines

Abstract

The invention discloses a method for constructing and storing biological tissue heterogeneous porous scaffolds based on B-spline bodies. Input the B-spline body model, grid discretize its parameter domain, set a scalar value for each grid point, select a three-variable B-spline function for iterative fitting, and construct the C value distribution field C(u,v ,w); Select the three-period minimal surface to define the implicit surface implicit function expression and generate the porous structure in the parameter domain; map the porous structure in the parameter domain to the B-spline body to generate a non-uniform porous scaffold, and judge whether the scaffold meets the actual needs, If it is not satisfied, locally modify the C value distribution field to regenerate the non-uniform porous scaffold; save and print the non-uniform porous scaffold model in TDF file format. The invention utilizes the C value distribution field to realize precise control of the porosity of the porous structure and local adjustment of the porosity, ensuring that the support model is smooth and continuous inside and the surface unit is complete, and at the same time, the TDF format greatly reduces the storage space compared with the traditional STL format .

Description

Technical field[0001]The present invention relates to a general computer-aided design and tissue engineering techniques, in particular, to the construction storage method of non-uniform porous brackets based on B-spline bio-tissue.Background technique[0002]Tissue engineering technology is one of the popular technologies in the field of medical life sciences, marking the coming of replication renewal organization and organ era, opening up new heavens and earth for the rise of regenerative medicine. With the in-depth study of cellular nuclear molecules, as well as the rapid development of material science and biotechnology, medical practitioners use the growth factor to cultivate human cells on tissue engineering brackets, re-transplanted to repair or replace the disease or Organs, as seed cells continue to increase and differentiate, the biomaterials of the stent are constantly degraded, and finally form tissue or organs consistent with the corresponding tissue or organ morphology an...

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Problems solved by technology

[0008] Since the current porous structure design methods mainly include two types of methods, one is to generate porous scaffolds by mapping regular TPMS units to each hexahedron of the hexahedral mesh model. This method causes each TPMS unit to be independent, and the interior cannot Well continuous, the performance of the porous structure depends on the quality of the hexahedral grid, and the porosity of the porous structure is not easy to control. The second is to immerse the model in a large TPMS structure and extract the porous structure through the intersection operation. This method The TPMS unit of the porous structure generated by design is not complete on the surface of the model, and the broken structure will affect the mechanical properties of the model

Most importantly, the porous scaffold files generated by the above methods are all saved in STL format, which greatly consumes storage space

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