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Nano inclusion compound capable of reducing blood glucose and preparation method of nano inclusion compound

An inclusion compound and hypoglycemic technology, applied in food science, food forming, function of food ingredients, etc., can solve the problems of nanoemulsion formula composition, complex preparation process, difficult removal of residual solvent, and unsuitable for food development, etc. Achieve the effect of improving islet beta cell function, good taste and beautiful appearance

Inactive Publication Date: 2019-11-12
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, organic solvents such as ether are often used for extraction in literature research, and residual solvents are difficult to remove, which is not suitable for food development
At present, the common functional products of Grifola frondosa are mainly oral solutions or compressed candies, and the main functional ingredients contained in them - polysaccharides are easily degraded by acid in gastric juice, and the large molecular weight leads to poor absorption. Therefore, some researchers have prepared them Nanoemulsion, etc. to improve bioavailability, but the composition and preparation process of nanoemulsion are relatively complicated

Method used

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  • Nano inclusion compound capable of reducing blood glucose and preparation method of nano inclusion compound
  • Nano inclusion compound capable of reducing blood glucose and preparation method of nano inclusion compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: Grifola frondosa raw material extraction

[0025] Take 10 parts of artificially cultured Grifola frondosa fruiting body powder, add 30 parts of water:ethanol=3:1 (volume ratio) ethanol aqueous solution, carry out reflux extraction for 2 hours, and dry to obtain the extract.

Embodiment 2

[0026] Embodiment 2: clathrate preparation process

[0027] Take 5 parts of chitosan, dissolve in 500mL 0.1% acetic acid solution, add 35 parts of Grifola frondosa extract, 5 parts of konjac glucomannan, and 1 part of collagen peptide, stir and mix evenly, and add 1 % sodium bicarbonate solution until pH = 7, freeze-dried for 30 hours, observed under a transmission electron microscope, the particle size was about 20 ± 5nm, granulated, dried, and compressed to make 1g / piece tablets.

Embodiment 3

[0028] Example 3: Preparation process of inclusion complex tablet

[0029] Take 5 parts of chitosan, dissolve in 500mL 0.1% acetic acid solution, add 20 parts of Grifola frondosa extract, 5 parts of konjac glucomannan, and 1 part of collagen peptide, stir and mix evenly, and add 1 % sodium bicarbonate solution until pH = 7, freeze-dried for 30 hours, pulverized, mixed with 0.1 part of steviol glycoside and 0.05 part of natural essence, granulated, dried and compressed to make 1 g / tablet. The obtained compressed tablet has obvious luster, good taste and pleasant smell.

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Abstract

The invention discloses a nano inclusion compound capable of reducing blood glucose and a preparation method of the nano inclusion compound and belongs to the technical field of functional food. The nano inclusion compound is prepared from a boletus frondosus dicks extract, dietary fiber and protein peptide by acid dissolution and addition of alkali liquor for neutralization. Raw materials of thenano inclusion compound are safe and reasonable in compatibility. Besides, the preparation method and process of the inclusion compound are simple to operate and good in repeatability, and obtained granules or tablets have attractive appearance, high wear resistance and good formability. Experiments prove that the inclusion compound has effects of gastric acid resistance and slow release, in a hyperglycemia mouse model, after 2 weeks of intragastric administration, the fasting blood-glucose decrease rate of the model is 39.5%, the functions of pancreatic beta cells can be effectively improved,and blood glucose can be reduced. The formula has excellent taste, can be used as a raw material of solid drinks or functional food and is widely applicable to diabetics.

Description

technical field [0001] The invention relates to a nano inclusion compound for lowering blood sugar and a preparation method thereof, belonging to the technical field of functional food. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to defects in insulin secretion or insulin action. Sustained high blood sugar and long-term metabolic disorders can lead to damage, dysfunction and failure of tissues and organs throughout the body, especially the eyes, kidneys, cardiovascular and nervous systems. Severe cases can cause acute complications such as dehydration, electrolyte disturbance and acid-base imbalance, ketoacidosis and hyperosmolar coma. With the continuous improvement and improvement of people's living conditions, the abundance and diversification of material life, and the fast-paced life, the number of patients with multiple diseases such as diabetes has increased sharply. [0003] The control of diabetes in mod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23L33/18A23L33/21A23P10/20A23P10/28
CPCA23L33/105A23L33/18A23L33/21A23P10/20A23P10/28A23V2002/00A23V2200/328A23V2250/21A23V2250/55
Inventor 蒋敏李恒刘朋史劲松许正宏
Owner JIANGNAN UNIV
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