Benzimidazolone compounds, and use thereof in antitussive and antiasthmatic drugs

A technology of benzimidazolone and compound, applied in the field of benzimidazolone compounds
CN110437155AInactive Publication Date: 2019-11-12王兴理
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
王兴理
Publication Date
2019-11-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses benzimidazolone compounds represented by formula I, or pharmaceutically acceptable salts thereof. Results of citric acid-induced guinea pig cough model effect test, capsaicin-induced mouse cough inhibition test, influences of the benzimidazolone compounds on guinea pig allergic asthma and calcium influx test of vanilloid receptors show that the compounds exhibit good antitussive and antiasthmatic effects by inhibiting vanilloid receptor 1.
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Description

technical field

[0001] The invention relates to the field of medicine, in particular to the use of benzimidazolone compounds in antitussive and antiasthmatic drugs. Background technique

[0002] Cough and asthma are the most common symptoms of respiratory diseases. After the sensory nerve endings are stimulated, the nerve impulses are transmitted along the vagus nerve to the cough center of the brainstem, and after the signal is integrated, it is transmitted to the effector through the efferent nerve, and finally leads to coughing action. The airway afferent nerves related to cough reflex mainly have myelinated Aδ fibers and unmyelinated C fibers, among which the myelinated Aδ fibers are sensitive to various mechanical stimuli; the unmyelinated C fiber endings are sensitive to various types of chemical stimuli . C fiber nerve endings contain the transient receptor potential vanilloid receptor 1 (TRPV 1 ), a variety of physical and chemical stimuli can directly or indirect...

Claims

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