Molecular marker for diagnosis of diabetes and application thereof
A molecular marker, a technology for diagnosing diabetes, applied in the field of molecular markers for diabetes diagnosis
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Embodiment 1
[0021] A molecular marker for diabetes diagnosis, comprising a test kit and diagnostic primers, characterized in that the kit is provided with a chip inside, the chip includes a gene chip, gene primers and molecular markers, and the diagnostic primers include A forward primer and a reverse primer, the forward primer and the reverse primer are both set to RNA molecular sequences; the molecular markers are set to the non-coding RNA molecular markers, and the non-coding RNA molecular markers are has- miR-802 and has-lncRNA-ROIT, the molecular markers were used as positive controls.
[0022] The gene chip includes a solid phase carrier and detection probes, the detection probes are fixed on the surface of the solid phase carrier, and the detection probes are oligonucleotide probes.
[0023] The gene primer is set as a primer reagent or probe for molecular markers, and a citric acid detection reagent is arranged inside the reagent or probe.
[0024] An application for diabetes dia...
Embodiment 3
[0035] A kind of molecular marker for the diagnosis of diabetes and its application provided by the embodiment and the second embodiment are clinically tested:
[0036] A normal control group was selected: 30 cases, 17 males and 13 females, with an average age of 54, 6±9, 6 years old, no history of infectious diseases, thrombosis, bleeding, and liver and kidney diseases, and no anticoagulants and contraceptives were used;
[0037] Type 2 DM group: 60 cases, 32 males and 28 females, with an average age of 55, 8±9, and 6 years old, diagnosed in line with the diagnostic criteria for diabetes established by WHO, with an average blood sugar concentration of 14, 16±5, 96mmol / L . Among them, 30 patients with no clinical complication of heart, brain, kidney and fundus vascular lesions belonged to the type 2 DM without clinical complication group;
[0038] 30 patients with one or more complications of heart, brain, kidney and fundus vascular lesions clinically belonged to the type 2 D...
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