Preparation method of 5-hydroxytryptophan sustained-release tablets

A technology of hydroxytryptophan and controlled-release tablets, which can be applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of high cost of 5-hydroxytryptophan matrix sustained-release tablets , to achieve the effects of good production controllability, relieving depression and increasing wear resistance

Inactive Publication Date: 2019-11-19
XIAN KELIKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the technical problem of high cost of 5-hydroxytryptophan matrix sustain

Method used

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  • Preparation method of 5-hydroxytryptophan sustained-release tablets
  • Preparation method of 5-hydroxytryptophan sustained-release tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation method of 5-hydroxytryptophan sustained and controlled release tablets, see the flow chart figure 1 , including the following steps:

[0033] Step S1, preparing 5-hydroxytryptophan crystals;

[0034] Step S2, granulating, drying, and tableting 5-hydroxytryptophan crystals to obtain a plain tablet; the process of preparing the plain tablet can use the preparation method in the prior art;

[0035] Step S3, coating the plain tablet with a slow-release coating premix, and adjusting the dosage of the slow-release coating premix according to the release rate to achieve the expected release rate;

[0036] Wherein the sustained-release coating premix comprises, by weight: 30 parts of ethyl cellulose, 2 parts of silicon dioxide and 1 part of walnut oil.

[0037] During the coating process, the weight ratio of the final coating to the plain tablet is controlled between 1:25 and 1:12, and a batch of several 5-hydroxytryptophan sustained-release tablets are prepar...

Embodiment 2

[0039] The preparation method of 5-hydroxytryptophan sustained and controlled release tablet comprises the following steps:

[0040] Step S1, preparing 5-hydroxytryptophan crystals;

[0041] Step S2, granulating 5-hydroxytryptophan crystals, drying, and tableting to obtain plain tablets;

[0042] Step S3, coating the plain tablet with a slow-release coating premix, and adjusting the dosage of the slow-release coating premix according to the release rate to achieve the expected release rate;

[0043] The sustained-release coating premix comprises, by weight, 70 parts of ethyl cellulose, 8 parts of titanium dioxide, and 6 parts of a mixture of rapeseed oil and soybean oil.

[0044] During the coating process, the weight ratio of the final coating to the plain tablet is controlled between 1:25 and 1:12, and a batch of several 5-hydroxytryptophan sustained-release tablets are prepared.

Embodiment 3

[0046] The preparation method of 5-hydroxytryptophan sustained and controlled release tablet comprises the following steps:

[0047] Step S1, preparing 5-hydroxytryptophan crystals;

[0048] Step S2, granulating 5-hydroxytryptophan crystals, drying, and tableting to obtain plain tablets;

[0049] Step S3, coating the plain tablet with a slow-release coating premix, and adjusting the dosage of the slow-release coating premix according to the release rate to achieve the expected release rate;

[0050] The slow-release coating premix comprises, by weight, 50 parts of ethyl cellulose, 5 parts of plant carbon black, a mixture of yellow iron oxide and 4 parts of sesame oil.

[0051] During the coating process, the weight ratio of the final coating to the plain tablet is controlled between 1:25 and 1:12, and a batch of several 5-hydroxytryptophan sustained-release tablets are prepared.

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Abstract

The invention discloses a preparation method of 5-hydroxytryptophan sustained-release tablets. The preparation method comprises the following steps that S1, a 5-hydroxytryptophan crystal is prepared;S2, the 5-hydroxytryptophan crystal is granulated, dried and tabletted to prepare naked tablets; and S3, the naked tablets are coated through a sustained-release coating premixing agent, and meanwhile, according to the need of the release speed, the dosage of the sustained-release coating premixing agent is adjusted to reach the expected release rate, wherein the sustained-release coating premixing agent is prepared from the following components in parts by weight: 30-70 parts of a main film forming material, 2-8 parts of an anti-blocking agent and 1-6 parts of a plasticizer. According to the5-hydroxytryptophan sustained-release tablets, the long-acting controlled release tablets are achieved through coating, the effective components can be released continuously at the constant speed, thestable blood concentration is kept, 5-hydroxytryptamine is provided for the brain continuously, black mood and depressive symptoms are continuously relieved, compared with 5-hydroxytryptophane skeleton sustained-release tablets, through coating sustained-release, the content of a sustained-release material accounts for 4% to 8% of the total amount of 5-hydroxytryptophane and does not exceed 10%,and the cost is significantly reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a method for preparing 5-hydroxytryptophan sustained and controlled release tablets. Background technique [0002] 5-Hydroxytryptophan (abbreviated as 5-HTP) is a natural plant extract with a molecular weight of 220.23. It has various biological activities and has been used as an important neurological drug and health product. [0003] 5-hydroxytryptophan can pass through the blood-brain barrier, and then converted into 5-hydroxytryptamine that cannot pass through the blood-brain barrier, and 5-hydroxytryptamine can regulate mood, promote melatonin secretion, thereby improving sleep, but 5-hydroxytryptamine metabolism is faster, and high doses It is easy to cause gastrointestinal discomfort. As a dietary supplement abroad, there are many skeleton sustained-release tablets. However, the cost of matrix sustained-release tablets is relatively high. In order to e...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/22A61K47/38A61K31/405A61P25/24
CPCA61K9/2866A61K31/405A61P25/24
Inventor 贾毅
Owner XIAN KELIKANG MEDICAL TECH CO LTD
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