Schizandrin A purity standard substance, preparation method thereof and application

A technology for schisandrin A and a standard substance, which is applied in the field of schisandrin A purity standard substance and its preparation, can solve the problem that it is difficult to meet the needs of pharmaceutical research and development of schisandra and its related products, and cannot effectively realize the verification of testing methods and arbitration of testing results. No traceability, etc.
CN110487612AInactive Publication Date: 2019-11-22上海诗丹德标准技术服务有限公司 +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
上海诗丹德标准技术服务有限公司
Publication Date
2019-11-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method for a schizandrin A purity standard substance. The preparation method comprises the following steps: a candidate for preparing the schizandrin A purity standard substance is extracted from a schisandra chinensis medicinal material; purity analysis and structure identification of the candidate are carried out; the uniformity of the candidate is checked;the stability of the candidate is checked; the purity constant value of the candidate is detected; uncertainty evaluation is carried out; and if the purity analysis, the structure identification, theuniformity check, the stability check and the uncertainty evaluation all meet the requirements, the schizandrin A purity standard substance is prepared. The invention also provides the schizandrin A purity standard substance prepared by the above method and application thereof. The schisandrin A purity standard substance disclosed by the invention can be used as a standard substance for accuratelydetecting the content of the schisandrin A component in related products produced by taking schisandra chinensis and kadsura longepedunculata as raw materials, and provides a standard substance resource with traceability and a quantity value transmission function for realizing accurate quantification of the content of the schisandrin A component in China.
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Description

technical field

[0001] The invention relates to a standard substance of schisandrin A purity and its preparation method and application, belonging to the technical field of standard value transmission in stoichiometric measurement. Background technique

[0002] Schisandra chinensis and Southern Schisandra chinensis have the effects of astringent and astringent, nourishing qi and promoting body fluid, tonifying kidney and calming heart. Schisandra chinensis and southern Schisandra chinensis contain a variety of chemical components, among which biphenyl cyclooctene lignans are the main active components, and schisandrin A is one of the important active components. Schisandrin A is a white crystalline powder with a CAS registration number of 61281-38-7 and a molecular formula of C 24 h 32 o 6 , the relative molecular weight is 416.51, soluble in chloroform, methanol, ethyl acetate, acetone, insoluble in water. Studies have found that Schizandrin A exhibits a variety of good...

Claims

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