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Molybdenum disulfide/diphenylalanine antibacterial agent, and preparation method and application thereof

A technology of diphenylalanine and molybdenum disulfide, which is applied in the field of antibacterial agents to achieve good antibacterial effects

Inactive Publication Date: 2019-11-26
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN108478597A discloses a polydopamine-modified molybdenum disulfide composite silver nanoparticle antibacterial agent and its preparation method; Chinese patent CN108392675A discloses a preparation method based on molybdenum disulfide and photosensitizer near-infrared photoresponsive nano-antibacterial coating ; Chinese patent CN106917131A discloses a preparation method of chitosan / molybdenum disulfide photocatalytic antibacterial coating, but there is no patent about bis-alanine

Method used

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  • Molybdenum disulfide/diphenylalanine antibacterial agent, and preparation method and application thereof
  • Molybdenum disulfide/diphenylalanine antibacterial agent, and preparation method and application thereof
  • Molybdenum disulfide/diphenylalanine antibacterial agent, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Antibacterial effect of molybdenum disulfide on Escherichia coli and Staphylococcus aureus

[0023] 1) Experimental bacteria

[0024] Foodborne pathogens:

[0025] Escherichia coli (Escherichia coli IFO 3301);

[0026] Staphylococcus aureus (Staphylococcus aureus 30179);

[0027] 2) Experimental method

[0028] Add certain concentration (0mg / mL, 0.025mg / mL, 0.05mg / mL, 0.1mg / mL) in phosphate buffered saline [Phosphate-Buffered Saline, PBS, 0.03mol / L, pH (7.2-7.4)] Molybdenum disulfide solution, and access to test bacteria Escherichia coli and Staphylococcus aureus (10 5 -10 6 CFU / mL), after shaking evenly, culture in a full-temperature air shaker at 37°C (150r / min), and take the group without molybdenum disulfide solution as a control, and use the plate colony counting method to determine the number of remaining bacteria. At 0h, 24h, and 48h, take an appropriate amount of culture solution and perform ten-fold gradient dilution to a suitable concentration, then pipe...

Embodiment 2

[0032] Antibacterial effect of molybdenum disulfide and diphenylalanine synergistically against methicillin-resistant Staphylococcus aureus (MRSA)

[0033] 1) Experimental bacteria

[0034] Nosocomial infection pathogenic bacteria:

[0035] Methicillin-resistant Staphylococcus aureus MRSA (Methicillin-resistant Staphylococcusaureus T34);

[0036] 2) Experimental method

[0037] In phosphate buffered saline [Phosphate-Buffered Saline, PBS, 0.03mol / L, pH (7.2-7.4)], add a synergistic antibacterial agent equal to the volume of the buffer, wherein the synergistic antibacterial agent consists of 5mg / mL dipropylamine acid (FF) solution and 0.025mg / mL molybdenum disulfide solution, insert the test bacteria (10 8 -10 9 CFU / mL), after adding and oscillating evenly, culture in a 37°C full-temperature air shaker (150r / min) and culture with only molybdenum disulfide and no diphenylalanine (FF) as the control group 1; Only add diphenylalanine (FF) without adding molybdenum disulfide a...

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Abstract

The invention relates to an antibacterial agent, and especially relates to a molybdenum disulfide / diphenylalanine antibacterial agent, and a preparation method and an application thereof. Antibacterial molybdenum disulfide is prepared by a hydrothermal technology, and is combined with the excellent antibacterial effect of diphenylalanine to prepare the novel antibacterial agent which is safe, green and free of toxic and side effects. The novel antibacterial agent can effectively inhibit growth of Escherichia coli and Staphylococcus aureus, and has obviously better antibacterial effect than single molybdenum disulfide and diphenylalanine.

Description

technical field [0001] The invention relates to an antibacterial agent, in particular to a synergistic antibacterial agent, specifically, the antibacterial effect of molybdenum disulfide and the self-assembly effect of diphenylalanine are used to prepare a safe and non-toxic synergistic antibacterial agent. Background technique [0002] There are many kinds of existing antibacterial agents, most of which use organic antibacterial agents with certain toxicity, such as vanillin or ethyl vanillin compounds. In this context, there is an urgent need for a safe and non-toxic antibacterial agent with broad-spectrum antibacterial effect in the field of life safety. [0003] Diphenylalanine (diphenylalanine, L-Phe-L-Phe, FF) is one of the smallest biological self-assembly materials, which is the core structure of Alzheimer's protein amyloid aggregation, consisting of two phenylalanines It is formed by dehydration condensation, has two benzene rings, and one end is amino-NH 2 , one ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/16A01N37/46A01P1/00
CPCA01N37/46A01N59/16
Inventor 崔海英李虹林琳柏梅
Owner JIANGSU UNIV