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Use of aucubin in preparing medicine for treating type 2 diabetes

A technology for aucubin and type 2 diabetes, applied in the field of medicine, can solve the problems of weakening, adverse side effects and the like, and achieve the effect of improving glucose and lipid metabolism

Inactive Publication Date: 2019-12-03
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral hypoglycemic agents currently available for the treatment of diabetes, such as sulfonylurea biguanides, α-glucosidase inhibitors, and thiazolidinediones, have adverse side effects or diminished responses after long-term use

Method used

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  • Use of aucubin in preparing medicine for treating type 2 diabetes
  • Use of aucubin in preparing medicine for treating type 2 diabetes
  • Use of aucubin in preparing medicine for treating type 2 diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1. Preparation of mouse type 2 diabetes model

[0024] Select 40 male SPF grade C57BL / 6J male mice aged 6 weeks, and house all the mice in an animal room with a constant temperature of 21-25°C and a humidity of 45-65%, and the room maintains a 12-hour light / dark cycle. The breeding process complied with the relevant guidelines for the management and protection of experimental animals.

[0025] The mice were first fed with normal feed for 1 week to adapt to the environment. Then randomly select 8 mice as the control group, and feed them with normal feed, and the rest of the mice are fed with high-fat feed. Four weeks after high-fat diet induction, the mice in the high-fat diet (HFD) group were intraperitoneally injected with streptozotocin (STZ) (30 mg / kg / d) for three consecutive days, and the mice in the control group were injected with normal saline. 72 hours after injection, the fasting blood glucose level of mice treated with HFD and STZ was higher than 11....

Embodiment 2

[0026] Example 2. Grouping and application of aucubin

[0027] (1) Control group (n=8) and model group (n=8): The control group (Control) and the diabetes model group (Diabetes) were intraperitoneally injected with an equal volume of normal saline for 4 consecutive weeks.

[0028] (2) Aucubin treatment group: Divided into 3 groups, 8 rats in each group: low dose aucubin group 1 mg / kg·day (1 mg / kg aucubin), medium dose aucubin group 5 mg / kg·day (5mg / kg aucubin) and 10 mg / kg·day (10mg / kg aucubin) in the high-dose group of aucubin were injected intraperitoneally continuously for 4 weeks. Body weight and fasting blood glucose of mice were recorded in detail every week.

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Abstract

The invention belongs to the technical field of medicine, and provides the use of aucubin in preparing a medicine for treating type 2 diabetes. A mouse model of type 2 diabetes is established by intraperitoneal injection of streptozotocin after 4 weeks of a high-fat diet. Then, aucubin is injected intraperitoneally at low, medium and high doses for 4 weeks respectively, four items of body weight,fasting blood glucose, insulin and blood lipid of mice are detected, the insulin resistance index and insulin sensitivity index are calculated, and the morphological changes of islets in pancreas areobserved by HE staining. The results show that the levels of insulin, TG, T-CHO and LDL-C in the serum of the mouse model of type 2 diabetes can be reduced, the level of HDL-C can be increased, and the insulin resistance index and insulin sensitivity index can be improved by aucubin in low, medium, and high doses of groups, compared with the model group. The atrophy of islets in the pancreas of the model mouse of type 2 diabetes is also improved by aucubin which has a better protective effect on the pancreas.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of aucubin in the preparation of medicines for treating type 2 diabetes. Background technique [0002] Diabetes Mellitus (DM) is a relatively common endocrine and metabolic disorder. There are many complications caused by diabetes, and it has become an increasingly serious public health problem worldwide, seriously affecting people's quality of life. Diabetes is generally divided into 4 categories: type 1 diabetes, type 2 diabetes, specific types of diabetes and gestational diabetes. Among them, type 2 diabetes mellitus (Type2DiabetesMellitus, T2DM) is the most common, accounting for about 90%-95% of the total number of diabetic patients. And cardiovascular and cerebrovascular diseases are called the three major diseases that threaten human health. Currently, oral hypoglycemic drugs such as sulfonylurea biguanides, α-glucosidase inhibitors and thiazolidine...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10A61P3/06
CPCA61K31/7048A61P3/10A61P3/06
Inventor 薛宏宇王宁刘亚军周玉荣姜丽丽毛晨晨徐品三
Owner DALIAN UNIV OF TECH
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