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Composition for improving liver function including fermented product of black radish lactic acid bacteria and method for producing fermented product of black radish lactic acid bacteria

A technology of lactic acid bacteria fermentation and manufacturing method, which can be applied to medical preparations containing active ingredients, drug combinations, functions of food ingredients, etc., and can solve the problems of inability to achieve diversification of black radish, difficult to ingest, and inability to separate active ingredients. , to achieve excellent antioxidant effect, improve liver function improvement effect, easy to ingest effect

Active Publication Date: 2021-03-09
KOLMAR BNH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, similar to other plants of the cruciferous family, Glucosinolate contained in vegetables is decomposed by Mirosinase as the black radish tissue is damaged to form isothiocyanate Isothiocyanate, which shows a spicy taste, especially compared with other types of radishes, the spicy taste is particularly strong, so there is a problem that it is not easy to eat
[0010] Therefore, although it has an excellent liver function improvement effect as described above, it is impossible to diversify the development of health function improvement foods using black radish, and it is limited to only the form of pickled radish, etc. covered by external seasonings.
In addition, the active ingredients contained in black radish that have the effect of improving liver function cannot be easily separated from the components that express the spicy taste, and the black radish extract also exhibits a spicy taste, so there is a problem in taking it as an extract

Method used

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  • Composition for improving liver function including fermented product of black radish lactic acid bacteria and method for producing fermented product of black radish lactic acid bacteria
  • Composition for improving liver function including fermented product of black radish lactic acid bacteria and method for producing fermented product of black radish lactic acid bacteria
  • Composition for improving liver function including fermented product of black radish lactic acid bacteria and method for producing fermented product of black radish lactic acid bacteria

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0082] Experimental Example 1-Antioxidant Efficacy Evaluation

[0083] In this experiment, in order to evaluate the antioxidant efficacy of black radish lactic acid bacteria fermentation products, ABTS radical cation removal activity, total polyphenols and total flavonoids content were measured.

[0084] Pretreatment of black radish lactic acid bacteria fermentation product

[0085]In order to evaluate the antioxidant effect of the sample in the powder state, 10% DMSO was added, ultrasonic extraction was performed for 30 minutes, and then the supernatant was used for the experiment. As a control group for each experiment, 10% DMSO was used.

[0086] ABTS radical cation removal activity

[0087] This experimental method is a method of measuring the degree to which the color of the reagent is lightened by removing ABTS radical cations from the sample. As the ABTS reagent, 2.45 mM potassium persulfate and 7 mM 2,2'-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium...

experiment example 2

[0099] Experimental Example 2-Evaluation of Hepatic Cell Protection Efficacy

[0100] In this experiment, in order to evaluate the liver function improvement effect of black radish lactic acid bacteria fermentation products, cytotoxicity measurement for setting the appropriate concentration of the sample and the fat globule formation inhibitory effect of Hep G2 cells and ethanol-treated cells were carried out. Evaluation of ALT and AST production inhibitory efficacy.

[0101] Cytotoxicity measurement

[0102] Before carrying out the experiment, as an MTT reagent, Thizolyl blue tetrazolium bromide (Sigma, USA) was dissolved in 1xPBS so that the final concentration reached 5 mg / ml, and then it was used while blocking light. To measure cytotoxicity, cells were incubated at 1 x 10 5 The cells / ml ramet 96-well plate was cultured for 24 hours, and each sample dissolved in the medium was treated according to each concentration (100ug / ml, 500ug / ml, 1000ug / ml) and cultured for 24 ho...

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Abstract

The present invention provides a composition for improving liver function including a fermented product of black radish lactic acid bacteria and a method for producing a fermented product of black radish lactic acid bacteria. Composition for improving liver function Composition for improving liver function which contains fermented product of black radish lactic acid bacteria containing black radish fermented product of lactic acid bacteria of the genus Lactobacillus (Lactobacillus spp.).

Description

technical field [0001] The present invention claims priority based on Korean Patent Application No. 10-2018-0062300 dated May 31, 2018, including all the contents disclosed in the Korean Patent Application as part of this specification. [0002] The present invention relates to a liver function improving composition containing a black radish lactic acid bacterium fermented product. The composition is a liver function improving composition containing a black radish fermented lactic acid bacterium of the genus Lactobacillus (Lactobacillus spp.). Background technique [0003] The liver is one of the important organs that detoxifies by synthesizing nutrients absorbed in the small intestine into metabolites or changing toxic substances into components for decomposition or excretion of substances that are harmless to the human body. In particular, the liver plays a role of emulsifying fat to generate bile so that fat can be easily absorbed in the small intestine, and also plays a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P1/04A23L19/00A23L29/00A23L33/00A61K36/21A61P1/16
CPCA23L19/01A23L29/065A23L33/00A61K36/21A61P1/16A23V2002/00A61K2236/19A23V2400/147A23V2400/125A23V2400/173A23V2400/169A23V2200/30A23L19/00A23L29/00A23L33/105A23L19/10
Inventor 金炫圭李学性金声恩白新和金基玉梁茶云洪承贤
Owner KOLMAR BNH CO LTD
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