Method for detecting local anesthetic in external product for adults
A detection method and product technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of no unified quality standard, low detection flux and sensitivity of high performance liquid chromatography, insufficient quantitative ability, etc., and achieve strong practicability , optimize detection, and improve the effect of sensitivity
Inactive Publication Date: 2019-12-10
广东省药品检验所
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Problems solved by technology
However, the quantitative capabilities of Raman spectroscopy and infrared spectroscopy are insufficient, and the detection throughput and sensitivity of high-performance liquid chromatography are inferior to those of liquid mass spectrometry.
[0006] At present, there is no unified quality standard for adult topical products. In order to ensure the follow-up research of adult topical products, it is necessary to carry out quality control
Method used
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Embodiment 1
[0041] LC-MS analysis method
[0042] Instruments and conditions:
[0043] LC-30AD liquid chromatograph, QTrap 5500 mass spectrometer, Japan Shimadzu company, distribution electrospray ion (ESI) source, American SCIEX company; Mili-Q Advantage A10 ultrapure water generator, American MILLIPORE company.
[0044] Lidocaine hydrochloride, ropivacaine mesylate, benzocaine, chloroprocaine hydrochloride and other standard products were purchased from China National Institutes for Food and Drug Control. Standard products such as prilocaine, procaine, bupivacaine, pramoxine hydrochloride, and oxybucaine were purchased from Shanghai Yuanye Biotechnology Co., Ltd.; dibucaine, tetracaine, and procaine Amine and other standard products were purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.; carbocaine, articaine and other standard products were purchased from Guangzhou Shuopu Biotechnology Co., Ltd.
[0045] Acetonitrile, methanol (chromatographically pure, Merck, Germany)...
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Abstract
The invention discloses a method for detecting illegally added 14 local anesthetic chemicals in an external product for adults. According to the method, qualitative and quantitative detection is carried out by adopting a liquid chromatography-mass spectrometry technical means. Quantification is performed by using a matrix matching standard working curve, so that the quantification accuracy of themethod is ensured. A preset multi-reaction monitoring (sMRM) mode is adopted, so that the sensitivity of the method is improved. The method is accurate and reliable, is simple and convenient to operate, can be used for simultaneously detecting the 14 local anesthetic chemicals in external products for adults, and provides a supervision and detection method for guaranteeing the safety of national sexual products.
Description
technical field [0001] The invention belongs to the field of drug analysis and detection, and relates to a detection method for local anesthetics in adult external products. Background technique [0002] With the rapid development of my country's economy, my country has become a big country in the production and consumption of pharmaceuticals. The pharmaceutical industry is prone to a series of negative problems. The most concerned issue is the illegal addition of chemical drugs to various products. Among them, products with aphrodisiac effects are the hardest hit areas where chemical drugs are illegally added. Such products can be divided into internal use and external use according to the way of use. [0003] In oral aphrodisiac products, the most illegally added chemical drugs are PDE5 (phosphodiesterase type 5) inhibitors. The state has issued a variety of relevant testing standards to monitor the safety of such products, and researchers have been studying PDE type 5 i...
Claims
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IPC IPC(8): G01N30/02G01N30/72
CPCG01N30/02G01N30/72
Inventor 庄玥黄艳婷梁祁
Owner 广东省药品检验所