A kind of polyarylether nitrile with antibacterial properties and its surface modification method
A technology of naphthalene biphenyl polyarylene ether and polyarylene ether nitrile is applied in the field of antibacterial materials containing naphthalene biphenyl structure polyarylene ether nitrile and its preparation, so as to improve biocompatibility and antibacterial activity, improve biological Compatibility and antibacterial activity, effectiveness in controlling bacterial growth
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Embodiment 1
[0046] Embodiment 1 prepares modified polyarylether nitrile antibacterial material
[0047] In the first step, after the powder is hot-pressed, the PPENK board is washed with deionized water, ethanol, acetone and deionized water in sequence, and dried for later use. Put the PPENK plate into 4mol / L KOH solution, condense and reflux at 102°C and carry out magnetic stirring. The reaction time is 24 hours. After the reaction, put the product HPPENK sheet into 1mol / L hydrochloric acid solution. Minutes later, the material is washed and dried for later use;
[0048] In the second step, put HPPENK into 10mL of water, add 0.7668g of EDC and 0.1151g of NHS, and magnetically stir at room temperature for 2 hours to activate the carboxyl groups on the surface of the HPPENK sample. After the reaction, wash the sample three times with deionized water. Immerse the surface-activated HPPENK sheet into a PBS solution of ethylenediamine with a volume fraction of 1% (v / v), stir at room temperatu...
Embodiment 2
[0084] In the first step, after the PPENK powder is hot-pressed, the PPENK board is washed with deionized water, ethanol, acetone and deionized water in sequence, and dried for later use. Put PPENK tablets into 4mol / L KOH solution, condense and reflux at 102°C and carry out magnetic stirring. The reaction time is 24 hours. After the reaction, put the product HPPENK tablets into 1mol / L hydrochloric acid solution, over 5 Minutes later, the material is washed and dried for later use;
[0085] In the second step, put HPPENK into 10mL water, add 0.7668g of EDC and 0.1151g of NHS, and magnetically stir at room temperature for 2 hours to activate the carboxyl groups on the surface of the HPPENK sample. After the reaction, wash the sample three times with deionized water.
[0086] The third step is to synthesize peptide 3
[0087] Accurately weigh 1.192g (4.38mmol) Boc-L-Lys-NCA and add it to a 50mL Shrek bottle, then add it to 15mL anhydrous DMF, and add 0.292g (0.146mmol) Boc-PEG a...
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