Cell necrosis inhibitor, and preparation method and application thereof

A compound, unsubstituted technology, used in anti-inflammatory agents, antibacterial drugs, pharmaceutical formulations, etc., can solve problems such as limited research and clinical applications, inability to enter the central nervous system through the blood-brain barrier, and poor pharmacokinetic properties.
CN110642874AActive Publication Date: 2020-01-03SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
5 Cites 8 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
Publication Date
2020-01-03

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a cell necrosis inhibitor, and a preparation method and application thereof. Particularly, the invention provides an inhibitor for inhibiting cell necrosis and / or human receptorinteracting protein 1 kinase (RIP1). The inhibitor has a structure shown as in a following formula I. The compound and a composition comprising the compound are useful in the prevention and / or treatment of diseases involving cell death and / or inflammation.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to an inhibitor for inhibiting cell necrosis and / or human receptor-interacting protein 1 kinase (RIP1), a preparation method and application thereof. The compounds and compositions comprising them can be used in methods for the prevention and / or treatment of diseases involving cell death and / or inflammation. Background technique

[0002] Programmed necrosis cell death, also known as programmed necrosis, is a new type of cell death discovered in recent years. Necroptosis, a highly inflammatory form of cell death, is considered an important pathological factor in a variety of degenerative and inflammatory diseases. These diseases include neurodegenerative diseases, stroke, coronary heart disease, myocardial infarction, retinal degenerative diseases, inflammatory bowel disease, kidney disease, liver disease, and various other related diseases.

[0003] Tumor necrosis factor alpha (TNF-α)-induced activation of NF-κB plays a central ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More