Zoom detection system for fluorescence imaging

Abstract

The invention discloses a zoom detection system for fluorescence imaging. The zoom detection system comprises a camera, a back focal length adjusting mechanism, a motorized filter wheel and a motorized zoom lens, wherein the motorized zoom lens is connected to the bottom of the motorized filter wheel; and the back focal length adjusting mechanism is connected between the camera and the motorized filter wheel and used for adjusting the distance between the camera and the motorized filter wheel. The structure of overall fluorescence imaging equipment can be simplified while a focal length setting function is guaranteed, and development of miniaturization and portability of products is facilitated. Excited fluorescence firstly enters the lens and then enters the filter wheel, the problem of partial loss of excited fluorescence due to limitation of the diameter of the filter wheel is solved, and the detection accuracy and precision can be further improved. The back focal length adjusting mechanism can adjust the distance between the camera and the motorized zoom lens, the lens can be matched with multiple cameras, and change of the lens during replacement of core components of the system is reduced.

Description

technical field [0001] The invention relates to the technical field of fluorescence imaging, in particular to a zoom detection system for fluorescence imaging. Background technique [0002] In recent years, with the development of biology, fluorescence imaging equipment has been more and more widely used. Its real-time imaging in vivo, no damage to organisms, long-term observation and monitoring and other advantages ensure the normal physiological activities of experimental organisms to the greatest extent and avoid artificial Interference and destruction of factors. Fluorescence imagers are mainly aimed at qualitative and quantitative studies of biological tissues, cells, and even molecular levels. Fluorescence imaging is especially suitable for in vivo imaging of viruses with specific optical molecular markers through genetic modification or chemical modification. [0003] At present, the detection system of the fluorescence imaging device is mainly composed of a CCD came...

AI Technical Summary

Problems solved by technology

At present, this fluorescent imaging detection device mainly has the following shortcomings: First, it needs to adjust the lens and the working distance to be detected to focus, and a complete motion system is required, which makes the system complex and bulky

Second, the excited fluorescence first passes through the filter wheel and then enters the lens. Due to the limitation of the diameter of the filter wheel, the excited fluorescence will be partially lost

Third, the current scientific research cameras rarely have a rear focus adjustment system, and the matching of the lens and the camera is not flexible enough

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