Non-invasive living electron spin resonance method and system

Abstract

The invention provides a method for safely generating non-paired electrons in a living or non-living biological sample through a non-invasive high-voltage discharge device. Under the condition that exogenous paramagnetic substances are not poured or implanted, the tissue structure and the physiological activity of the living or non-living biological sample can be detected by applying an electron spin resonance (ESR) technology, the information of a neural medium activity, biomolecular metabolism, an acceptor and chemical components is further obtained, and therefore, a non-invasive living bodyelectron spin resonance spectrometer & imaging-brain computer interface (ESRI-BCI) system is formed.

Description

technical field [0001] The present disclosure relates to electron spin resonance (ESR), in particular to a non-invasive in vivo electron spin resonance spectrometer, three-dimensional imager and brain-computer interface (Electron Spin Resonance Spectrometer & Imaging- Brain Computer Interface, ESRI-BCI) system. Background technique [0002] Electron spin resonance (ESR), also known as electron paramagnetic resonance (EPR), was first observed by E. Zavoisky in 1944. Earlier, Isidor Rabi first described and measured nuclear magnetic resonance (NMR) of molecular beams in a further Stern–Gerlach experiment in 1938, Edward Mills Purcell and Felix Bloch observed the same phenomenon in solids and liquids respectively in 1946 . [0003] Nuclear Magnetic Resonance (NMR) is a phenomenon in which atomic nuclei absorb and re-emit electromagnetic waves in a magnetic field. Magnetic Resonance Imaging (MRI), originally called Nuclear Magnetic Resonance Imaging (NMRI), is a form of NMR an...

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Problems solved by technology

[0007] The above examples reflect the fact that for living biological samples, the signal observation of the current ESR system is completely dependent on the perfusion or implantation of exogenous paramagnetic substances, which is unacceptable in the usual field of medical diagnosis. This is also the main reason why ESR technology has not been widely used.

[0008] On the other hand, MRI also has many disadvantages, including particularly expensive manufacturing and operating costs, long scanning time required to obtain ideal spatial resolution, etc. Usually, MRI with a magnetic field strength of 0.1T~3T takes 10~ 30 minutes

The magnet is the largest and most expensive part of an MRI scanner. Most low-field MRI scanners below 0.75T use permanent magnets, and some models can even exceed 100 tons in weight. They are very bulky and heavy, and their accuracy and temperature stability are limited. , permanent magnets also have special safety concerns: because their magnetic fields cannot be "turned off," ferromagnetic objects are difficult to remove once they come into direct contact

[0013] In summary, MRI, BOLD fMRI, MEG, and PET represent the highest level of current medical imaging technology. ESR has also been successfully applied to the study of paramagnetic substances, but it is bulky, extremely expensive, unresponsive, reagent perfusion, and nuclear imaging. Radiation exposure has always been a drawback for them to overcome

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