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Application of 27-hydroxycholesterol to preparation of product for diagnosing schizophrenia

A technology for hydroxycholesterol and schizophrenia, applied in the direction of disease diagnosis, analytical materials, material inspection products, etc., can solve the problems of unfavorable disease prognosis, lack of pathological diagnosis indicators, etc., and achieve convenient promotion and use, high sensitivity and specificity, and convenient The effect obtained

Pending Publication Date: 2020-01-17
BEIJING ANDING HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most mental diseases, especially schizophrenia, lack specific pathological diagnostic indicators. Clinical diagnosis can only be judged by clinical experience after symptom description and duration and exclusion of other diseases. Delayed or misdiagnosed diagnosis has no effect on the prognosis of the disease. very unfavorable

Method used

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  • Application of 27-hydroxycholesterol to preparation of product for diagnosing schizophrenia
  • Application of 27-hydroxycholesterol to preparation of product for diagnosing schizophrenia
  • Application of 27-hydroxycholesterol to preparation of product for diagnosing schizophrenia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1: the collection of peripheral blood and the method for measuring the concentration of peripheral blood 27OHC

[0059] 1. According to the experimental protocol and diagnostic criteria that have passed the ethical review, the healthy control population (HC), the genetically high risk of schizophrenia (first-degree relatives of the patient, FDR), the clinical ultra-high risk (UHR) and the patients with schizophrenia ( SCZ) 4 groups with a total of 312 people. The entry criteria for each group are as follows:

[0060] Healthy controls: using the Structured Clinical Interview for DSM Disorders-Fourth Edition (DSM-IV) clinical interview (Structured Clinical Interview for DSM-IV Axis I disorders-Patient Edition, SCID-I / P ) and SIPS screening showed no mental illness and no family history of mental illness.

[0061] Inclusion criteria for patients with schizophrenia: in line with the diagnostic criteria of the fourth edition of the American Diagnostic and Statis...

Embodiment 2

[0074] Example 2: Peripheral blood 24OHC or 27OHC is used as a biomarker for the diagnosis of schizophrenia

[0075] 1. A total of 312 gender-matched subjects were included in this study. The basic demographic information and patient symptom assessment of each group are shown in Table 2.

[0076] Table 2: Basic demographics of subjects and evaluation of clinical symptoms of patients

[0077]

[0078] Note: HC: healthy controls; FDR: first-degree relatives of schizophrenia; UHR: clinical ultra-high risk of schizophrenia; SCZ: patients with schizophrenia; SIPs: schizophrenia risk syndrome structured interviews; PANSS: positive and negative symptoms scale; P: positive symptoms; N: negative symptoms; G: general psychotic symptoms: T: total score; NA: missing value.

[0079] After the detection of plasma 27OHC, it was found that compared with the healthy control group, the plasma 27OHC level of patients with schizophrenia was significantly lower ( figure 1 , pfigure 1 ), indic...

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Abstract

The invention provides application of 27-hydroxycholesterol or a reagent for detecting the 27-hydroxycholesterol to preparation of a reagent or kit for diagnosing schizophrenia. The 27-hydroxycholesterol can be used as a biomarker for diagnosing schizophrenia, has relatively high sensitivity and specificity for the diagnosis of schizophrenia, can be applied to diagnosis and prediction only by thedetermination of one index of peripheral blood 27-hydroxycholesterol level, and is convenient for popularization and use.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to the application of brain cholesterol metabolite 27-hydroxycholesterol (27OHC) in the diagnosis of schizophrenia and the application of preparing corresponding reagents. Background technique [0002] Schizophrenia is a common mental illness and a major public health problem affecting economic and social development. Schizophrenia is one of the most serious and complex neuropsychiatric diseases with unknown etiology, poor prognosis, and high disability rate. Its clinical symptoms mainly include hallucinations, delusions, neurophysiological dysfunction, and neurocognitive dysfunction. In recent years, the development of neuroimaging, genomics, proteomics, and immunohistochemistry has provided important tools for understanding the etiology of schizophrenia at the genetic and cellular levels, but the pathophysiological mechanism of schizophrenia is still unclear. clear. [0...

Claims

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Application Information

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IPC IPC(8): G01N33/92
CPCG01N33/92G01N2800/302G01N2800/52
Inventor 李人孙作厘王传跃
Owner BEIJING ANDING HOSPITAL CAPITAL MEDICAL UNIV
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